Four-month treatment with GLP-2 significantly increases hip BMD: a randomized, placebo-controlled, dose-ranging study in postmenopausal women with low BMD

DB Henriksen, P Alexandersen, B Hartmann…�- Bone, 2009 - Elsevier
… increase in total hip BMD. The change in total hip BMD between Treatment Days 2 and 121
… to placebo for the 3.2 mg GLP-2 group (P = 0.007) and for the 1.6 mg GLP-2 group (P = 0.042…

Effects of GLP‐1 receptor agonists on bone mineral density in patients with type 2 diabetes mellitus: a 52‐week clinical study

T Cai, H Li, L Jiang, H Wang, M Luo…�- BioMed Research�…, 2021 - Wiley Online Library
… to assess the changes of BMD, especially the total hip of BMD. … , GLP-1RAs have an effect
of maintaining BMD and provide a treatment option for patients with osteoporosis and type 2

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

SBK Jensen, V S�rensen, RM Sandsdal…�- JAMA network�…, 2024 - jamanetwork.com
2 diabetes, total and hip BMD was unchanged after modest weight loss induced by 1.8 mg of
liraglutide. The GLP-1RA exenatide was associated with increased hip BMD … risk with GLP-…

[HTML][HTML] Subcutaneous GIP and GLP-2 inhibit nightly bone resorption in postmenopausal women: a preliminary study

K Skov-Jeppesen, S Veedfald, S Madsbad, JJ Holst…�- Bone, 2021 - Elsevier
… Moreover, GLP-2 has been shown to dose-dependently increase BMD after four months of
… long-term GLP-2 treatment. Importantly, significant increases in BMD of total hip, trochanter, …

Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes

K Skov-Jeppesen, CB Christiansen…�- The Journal of�…, 2024 - academic.oup.com
… treatment significantly and dose dependently increased BMD in postmenopausal women
(29). It is unknown whether GLP-2 also decreases bone resorption in T2D, but the effect may …

Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

KV Haderslev, PB Jeppesen, B Hartmann…�- Scandinavian Journal�…, 2002 - Taylor & Francis
… This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and
biochemical markers of bone turnover in these patients. Methods: In an open-labelle d pilot …

Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study

LD Carbone, P Bůžkov�, HA Fink, JA Robbins…�- Osteoporosis�…, 2017 - Springer
… of the incretin hormones glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2),
and … Osteoblasts and osteoclasts that variably express receptors for GIP, GLP-1, and GLP-2, …

GLP-2 and GIP exert separate effects on bone turnover: a randomized, placebo-controlled, crossover study in healthy young men

K Skov-Jeppesen, MS Svane, C Martinussen…�- Bone, 2019 - Elsevier
GLP-2 treatment shows no sign of tachyphylaxis or generation of GLP-2 antibodies [10,11]
and four months of GLP-2 … to increase bone mineral density (BMD measured by DEXA) [11]. …

Risk of fracture with dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in real-world use�…

K Hidayat, X Du, BM Shi�- Osteoporosis International, 2019 - Springer
… with a small reduction in the total BMD at the hip but not at other skeletal sites. However,
the authors noted that the reduced BMD with canagliflozin treatment was unlikely due to its …

[HTML][HTML] The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus

LSG Lopes, RP Schwartz, B Ferraz-de-Souza…�- Diabetology & metabolic�…, 2015 - Springer
… cannot ascertain that GLP-2 is responsible for the abnormal bone remodeling in T2D.
Nevertheless, we found a positive correlation between GLP-2 and femoral neck and total hip BMD, …