Within EuroFlow, we recently developed screening tubes for hematological malignancies
and immune deficiencies. Pipetting of antibodies for such 8-color 12-marker tubes however is …

Next generation sequencing has enabled rapid diagnosis of patients with monogenic
diseases and discovery of novel disease-causing variants. However, the functional …

Sea anemone venoms contain diverse toxins most of which target voltage-gated sodium
channels (NaV). More than fifty toxins of four distinct structural types have been isolated and …

Acid-sensing ion channels (ASICs) have been known as sensors of a local pH change within
both physiological and pathological conditions. ASIC-targeting peptide toxins could be …

Background Humoral immunocompetence develops stepwise throughout life and contributes
to individual susceptibility to infection, immunodeficiency, autoimmunity, and neoplasia. …

The receptor tyrosine kinase (RTK) EphA2 is expressed in epithelial and endothelial cells
and controls the assembly of cell–cell junctions. EphA2 has also been implicated in many …

510a Wednesday, February 22, 2023 headgroups, but without the G-protein. Consistent with
our hypothesis, the TM6–TM7 interactions are similar to the G-protein coupled state in the …

Background Predominantly antibody deficiencies (PADs) are the most prevalent primary
immunodeficiencies, but their B-cell defects and underlying genetic alterations remain largely …

The Unfolded Protein Response (UPR) is a signaling network that responds to an increased
load of unfolded proteins within the Endoplasmic Reticulum (ER), referred to as ER stress. …

The European economy has finally started growing again, but the news to date is hardly cause
for celebration. The European standard of living as measured by gross domestic product …