Cyclic adenosine monophosphate (cAMP) is an intracellular signaling molecule responsible
for directing cellular responses to extracellular signals. Once believed to signal exclusively�…

We hypothesized that pulmonary granulocyte-macrophage colony-stimulating factor (GM-
CSF) is critically involved in determining the functional capabilities of alveolar macrophages�…

Abnormal proliferation of pulmonary fibroblasts is a prominent feature of chronic pulmonary
fibrotic diseases such as idiopathic interstitial pneumonia (IIP), but it is not presently clear�…

Langerhans-cell-enriched epidermal cell preparations, when pulsed with antigen, can
induce proliferative responses, in immune T cells, that are of the same magnitude as those�…

Multipotent mesenchymal progenitor cells, termed “mesenchymal stem cells”(MSCs), have
been demonstrated to reside in human adult lungs. However, there is little information�…

Dendritic cells (DC) migrate from sites of inflammation to lymph nodes to initiate primary
immune responses, but the molecular mechanisms by which DC are replenished in the�…

To determine whether TLR9 signaling contributes to the development of the adaptive
immune response to cryptococcal infection, wild-type (TLR9+/+) and TLR9 knockout�…

Rationale: Prostaglandin (PG) E2, a cyclooxygenase-derived lipid mediator, is a potent
down-regulator of fibroblast activation in normal lung fibroblasts. Although fibroblasts from�…

Rationale: Bronchoalveolar lavage fluid (BAL) from human lung allografts demonstrates the
presence of a multipotent mesenchymal stromal cell population. However, the clinical�…

The success of bone marrow transplantation (BMT) as a therapy for malignant and inherited
disorders is limited by infectious complications. We previously demonstrated syngeneic BMT�…