Although the surface determinants encoded by class I genes of the major histocompatibility
complex (murine K/D; human HLA-A/B/C) are expressed on virtually all nucleated cells, the�…

Plasminogen activation to plasmin protects from lung fibrosis, but the mechanism underlying
this antifibrotic effect remains unclear. We found that mice lacking plasminogen activation�…

The composite physiologic index (CPI) was derived to represent the extent of fibrosis on
high-resolution computed tomography (HRCT), adjusting for emphysema in patients with�…

The development of T1-cell-mediated immunity is required to clear a pulmonary
Cryptococcus neoformans infection. The objective of these studies was to determine the�…

Idiopathic pulmonary fibrosis is characterized by diffuse alveolar damage and severe
fibrosis, resulting in a steady worsening of lung function and gas exchange. Because�…

CCR2 and its major ligand, chemokine ligand 2 (CCL2)/monocyte chemotactic protein-1,
have been found to influence T1/T2 immune response polarization. Our objective was to�…

Mice with a null deletion mutation in the gamma interferon (IFN-γ) receptor gene were used
to study the role of IFN-γ responsiveness during experimental pulmonary cryptococcosis�…

After intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans,
12-wk survival was> 90% for CCR5+/+ mice but< 25% for CCR5−/− mice. There were no�…

Background Idiopathic pulmonary fibrosis exhibits differential progression from the time of
diagnosis but the molecular basis for varying progression rates is poorly understood. The�…

Idiopathic pulmonary fibrosis is a disease that is characterized by fibroblast accumulation
and activation in the distal airspaces of the lung. We hypothesized that fibrotic lung�…