Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99
Y Zhang, F Wang, KC Tompkins, A McNamara…�- The American journal of�…, 2009 - Elsevier
The present study dissected the role of a Th2 bias in pathogenesis of Cryptococcus
neoformans H99 infection by comparing inhalational H99 infections in wild-type BALB/c and�…
neoformans H99 infection by comparing inhalational H99 infections in wild-type BALB/c and�…
Steroids in idiopathic pulmonary fibrosis: a prospective assessment of adverse reactions, response to therapy, and survival
KR Flaherty, GB Toews, JP Lynch III…�- The American journal of�…, 2001 - Elsevier
PURPOSE: We evaluated the risk and potential benefit of high-dose corticosteroid therapy in
patients with idiopathic pulmonary fibrosis. SUBJECTS AND METHODS: We prospectively�…
patients with idiopathic pulmonary fibrosis. SUBJECTS AND METHODS: We prospectively�…
Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans
S Arora, MA Olszewski, TM Tsang…�- Infection and�…, 2011 - Am Soc Microbiol
The immune response to Cryptococcus neoformans following pulmonary infection of
C57BL/6 wild-type (WT) mice results in the development of persistent infection with�…
C57BL/6 wild-type (WT) mice results in the development of persistent infection with�…
Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
JE Kolodsick, GB Toews, C Jakubzick…�- The Journal of�…, 2004 - journals.aai.org
Intratracheal injection of FITC results in acute lung injury and progresses to fibrosis by day
21 postchallenge. In response to FITC, BALB/c mice produce IL-4 and IL-13 in the lung. To�…
21 postchallenge. In response to FITC, BALB/c mice produce IL-4 and IL-13 in the lung. To�…
Down-regulation of the afferent phase of T cell-mediated pulmonary inflammation and immunity by a high melanin-producing strain of Cryptococcus neoformans.
GB Huffnagle, GH Chen, JL Curtis…�- …�(Baltimore, Md.: 1950�…, 1995 - journals.aai.org
The interaction (s) between cryptococcal virulence factors and leukocytes involved in
generating protective cell-mediated immunity is not well defined. Intratracheal inoculation of�…
generating protective cell-mediated immunity is not well defined. Intratracheal inoculation of�…
Role of IFN-γ in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis
S Arora, Y Hernandez, JR Erb-Downward…�- The Journal of�…, 2005 - journals.aai.org
Pulmonary Cryptococcus neoformans infection of C57BL/6 mice is an established model of
a chronic pulmonary fungal infection accompanied by an “allergic” response (T2) to the�…
a chronic pulmonary fungal infection accompanied by an “allergic” response (T2) to the�…
Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung
JJ Osterholzer, R Surana, JE Milam…�- The American journal of�…, 2009 - Elsevier
Urease, a major virulence factor for Cryptococcus neoformans, promotes lethal meningitis/
encephalitis in mice. The effect of urease within the lung, the primary site of most invasive�…
encephalitis in mice. The effect of urease within the lung, the primary site of most invasive�…
Production of prostaglandins and leukotrienes by pathogenic fungi
MC Noverr, GB Toews, GB Huffnagle�- Infection and immunity, 2002 - Am Soc Microbiol
These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and
systemic) have the ability to produce eicosanoids both from simple metabolites and from�…
systemic) have the ability to produce eicosanoids both from simple metabolites and from�…
Role of Dendritic Cells and Alveolar Macrophages in Regulating Early Host Defense against Pulmonary Infection with Cryptococcus neoformans
JJ Osterholzer, JE Milam, GH Chen…�- Infection and�…, 2009 - Am Soc Microbiol
Successful pulmonary clearance of the encapsulated yeast Cryptococcus neoformans
requires a T1 adaptive immune response. This response takes up to 3 weeks to fully�…
requires a T1 adaptive immune response. This response takes up to 3 weeks to fully�…
Prostaglandin E2 Synthesis and Suppression of Fibroblast Proliferation by Alveolar Epithelial Cells Is Cyclooxygenase-2–Dependent
Alveolar epithelial cells (AECs) may influence neighboring fibroblasts by the elaboration of
prostaglandin E2 (PGE2). This prostanoid can be synthesized via “constitutive”�…
prostaglandin E2 (PGE2). This prostanoid can be synthesized via “constitutive”�…