A histologic feature of usual interstitial pneumonia is the presence of fibroblastic foci. As
some patients with usual interstitial pneumonia and an underlying collagen vascular�…

Rationale: Treatment and prognoses of diffuse parenchymal lung diseases (DPLDs) varies
by diagnosis. Obtaining a uniform diagnosis among observers is difficult. Objectives�…

To investigate the pathogenesis of Legionnaires disease at a molecular level, we mutated
by directed allelic exchange a gene encoding a Legionella pneumophila-specific 24,000�…

Rationale: Idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial pneumonias
(IIPs) have similar clinical and radiographic features, but their histopathology, response to�…

Rationale: Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF).
Defining mechanisms of myofibroblast differentiation may be critical to the development of�…

Objective In diffuse parenchymal lung diseases, the evolution of pulmonary fibrosis is often
devastating and may result in death. In this study the role of CCL18 as a biomarker of�…

Abstract Development of allograft rejection continues to be the major determinant of
morbidity and mortality postlung transplantation. We have recently demonstrated that a�…

The development of T cell immunity is required to clear a pulmonary Cryptococcus
neoformans infection (via the recruitment and activation of inflammatory cells). The objective�…

Pulmonary clearance of the encapsulated yeast Cryptococcus neoformans is associated
with the CCR2-mediated accumulation of lung dendritic cells (DC) and the development of a�…

Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with
pulmonary vasculopathy. Objective The purpose of this study was to determine whether�…