Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We
hypothesized that desaturation during a 6-minute walk test would predict mortality for�…

Background: High resolution computed tomography (HRCT) has an important diagnostic
role in idiopathic interstitial pneumonia (IIP). We hypothesised that the HRCT appearance�…

Bone marrow-derived cells are known to play important roles in repair/regeneration of
injured tissues, but their roles in pathological fibrosis are less clear. Here, we report a critical�…

Idiopathic interstitial pneumonias are a diverse group of lung diseases with varied
prognoses. We hypothesized that changes in physiologic and radiographic parameters�…

Idiopathic pulmonary fibrosis (IPF) is associated with significant morbidity and mortality
despite aggressive therapy. Thirty-eight patients with biopsy-proven IPF were studied to�…

Rationale: Recently, models of macrophage activation have been revised. Macrophages
stimulated with Th2 cytokines have been classified as alternatively activated. Objectives�…

We have previously shown that mice that are genetically deficient in the CCR2 gene
(CCR2−/− mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis�…

Patients with idiopathic interstitial pneumonias (IIPs) can be subdivided into groups based
on the histological appearance of lung tissue obtained by surgical biopsy. The quantitative�…

Rationale and Hypothesis: Idiopathic pulmonary fibrosis is a fatal disease with a variable
rate of progression. We hypothesized that changes in distance walked and quantity of�…

Over the past four decades, there has been a significant increase in allergy and asthma in
westernized countries, which correlates with alterations in fecal microbiota (microflora) and�…