Clinical and experimental evidence indicates that tumor-associated macrophages (TAMs)
promote malignant progression. In breast cancer, TAMs enhance tumor angiogenesis, tumor�…

Abstract Colony stimulating factor‐1 (CSF‐1) is the primary regulator of the mononuclear
phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF‐1R, that�…

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and
neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal�…

Inflammatory bowel disease (IBD) is a high-risk condition for human colorectal cancer.
However, our mechanistic understanding of the link between inflammation and�…

Mammary gland development initiates postnatally with the development of terminal end
buds (TEBs) at the end of the rudimentary ducts. These grow out through the fat pad and�…

Neuropilin (NRP) 1 is a receptor for the vascular endothelial growth factor (VEGF)-A and is
essential for normal angiogenesis. Previous in vitro experiments identified NRP1�…

The CSF‐1 null mouse, osteopetrotic, has provided a powerful model in which to study the
biological functions of CSF‐1. In this review, I will describe our studies that have used this�…

Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all
tissues. These important cells not only are critical for regulating normal tissue homeostasis�…

During pregnancy the mouse uterine epithelial synthesis of the mononuclear phagocyte
growth factor designated colony-stimulating factor 1 (CSF-1) is regulated by female sex�…

Background & Aims Liver regeneration requires functional liver macrophages, which provide
an immune barrier that is compromised after liver injury. The numbers of liver macrophages�…