Abstract Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear
phagocytic lineage, is expressed in more than 70% of human breast cancers and its�…

Leucocytes are a major component of the tumour microenvironment. Recent studies have
indicated that the infiltration and activity of these host cells are regulated by the tumour to�…

WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and
stroma are the major source of WNT ligands but their origin and role in intestinal stem cell�…

Systemic infection with Listeria monocytogenes, a Gram-positive intracellular bacterium, has
been used extensively to analyze the innate immune response 1, 2. Macrophages are�…

Myeloid cells are a feature of most tissues. Here we show that during development, retinal
myeloid cells (RMCs) produce Wnt ligands to regulate blood vessel branching. In the mouse�…

Although the link between inflammation and cancer initiation is well established, its role in
metastatic diseases, the primary cause of cancer deaths, has been poorly explored. Our�…

Epithelial/mesenchymal cell interactions are necessary for proper ductal morphogenesis
throughout all stages of mammary gland development. Besides the well-established stromal�…

Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the
CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage�…

Meiosis is a double-division process that is preceded by only one DNA replication event to
produce haploid gametes. The defining event in meiosis is prophase I, during which�…

Estradiol-17β (E2) causes cell proliferation in the uterine epithelium of mice and humans by
signaling through its transcription factor receptor α (ERα). In this work we show that this�…