Resolving the fibrotic niche of human liver cirrhosis at single-cell level
P Ramachandran, R Dobie, JR Wilson-Kanamori…�- Nature, 2019 - nature.com
Liver cirrhosis is a major cause of death worldwide and is characterized by extensive
fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better�…
fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better�…
A timeline of tumour-associated macrophage biology
L Cassetta, JW Pollard�- Nature Reviews Cancer, 2023 - nature.com
Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant�…
populated by many immune cells, of which macrophages are among the most abundant�…
[HTML][HTML] A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
B Qian, Y Deng, JH Im, RJ Muschel, Y Zou, J Li…�- PloS one, 2009 - journals.plos.org
Background The stromal microenvironment and particularly the macrophage component of
primary tumors influence their malignant potential. However, at the metastatic site the role of�…
primary tumors influence their malignant potential. However, at the metastatic site the role of�…
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
B Kneitz, PE Cohen, E Avdievich, L Zhu…�- Genes &�…, 2000 - genesdev.cshlp.org
Msh4 (MutS homolog 4) is a member of the mammalian mismatch repair gene family whose
members are involved in postreplicative DNA mismatch repair as well as in the control of�…
members are involved in postreplicative DNA mismatch repair as well as in the control of�…
[HTML][HTML] Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and�…
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and�…
A pregnancy defect in the osteopetrotic (opop) mouse demonstrates the requirement for CSF-1 in female fertility
JW Pollard, JS Hunt, W Wiktor-Jedrzejczak…�- Developmental�…, 1991 - Elsevier
Correlative evidence suggests that maternal production of the mononuclear phagocyte
growth factor colony stimulating factor-1 (CSF-1) regulates placental development. In order�…
growth factor colony stimulating factor-1 (CSF-1) regulates placental development. In order�…
A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
RT Sasmono, D Oceandy, JW Pollard…�- Blood, The Journal�…, 2003 - ashpublications.org
The c-fms gene encodes the receptor for macrophage colony-stimulating factor (CSF-1). The
gene is expressed selectively in the macrophage and trophoblast cell lineages. Previous�…
gene is expressed selectively in the macrophage and trophoblast cell lineages. Previous�…
[HTML][HTML] Meiotic pachytene arrest in MLH1-deficient mice
Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary
nonpolyposis colon cancer. To understand the role of MLH1 in normal growth and�…
nonpolyposis colon cancer. To understand the role of MLH1 in normal growth and�…
Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse
MG Cecchini, MG Dominguez, S Mocci…�- …, 1994 - journals.biologists.com
ABSTRACT Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation and
differentiation of mononuclear phagocytes. The osteopetrotic (op/op) mutant mouse is�…
differentiation of mononuclear phagocytes. The osteopetrotic (op/op) mutant mouse is�…
[HTML][HTML] Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as�…
important roles in growth and development, tissue and organ regeneration, as well as�…