Mutational landscape of aggressive prostate tumors in African American men

KJ Lindquist, PL Paris, TJ Hoffmann, NJ Cardin…�- Cancer research, 2016 - AACR
Prostate cancer is the most frequently diagnosed and second most fatal nonskin cancer
among men in the United States. African American men are two times more likely to develop�…

Chromosome 17q12 variants contribute to risk of early-onset prostate cancer

AM Levin, MJ Machiela, KA Zuhlke, AM Ray…�- Cancer research, 2008 - AACR
In a recent genome-wide association study by Gudmundsson and colleagues, two prostate
cancer susceptibility loci were identified on chromosome 17q. The first locus, at 17q12, was�…

A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

ML Spear, D Hu, M Pino-Yanes, S Huntsman…�- The�…, 2019 - nature.com
Short-acting β2-adrenergic receptor agonists (SABAs) are the most commonly prescribed
asthma medications worldwide. Response to SABAs is measured as bronchodilator drug�…

Dog introduction alters the home dust microbiota

AR Sitarik, S Havstad, AM Levin, SV Lynch…�- Indoor�…, 2018 - Wiley Online Library
Research has largely reported that dog exposure is associated with reduced allergic
disease risk. Responsible mechanism (s) are not understood. The goal was to investigate�…

[HTML][HTML] Current treatment of bilateral retinoblastoma: the impact of intraarterial and intravitreous chemotherapy

JH Francis, N Roosipu, AM Levin, SE Brodie, IJ Dunkel…�- Neoplasia, 2018 - Elsevier
PURPOSE: To evaluate the management and outcomes of na�ve bilateral retinoblastoma
treated at a single-center over a 5-year period during the era of ophthalmic artery�…

Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

C Ober, CG McKennan, KM Magnaye…�- The Lancet�…, 2020 - thelancet.com
Background African ancestry is associated with a higher prevalence and greater severity of
asthma than European ancestries, yet genetic studies of the most common locus associated�…

Results from a prostate cancer admixture mapping study in African-American men

CH Bock, AG Schwartz, JJ Ruterbusch, AM Levin…�- Human genetics, 2009 - Springer
There are considerable racial disparities in prostate cancer risk, with a 60% higher
incidence rate among African-American (AA) men compared with European-American (EA)�…

Deletion of flbA Results in Increased Secretome Complexity and Reduced Secretion Heterogeneity in Colonies of Aspergillus niger

P Krijgsheld, BM Nitsche, H Post…�- Journal of proteome�…, 2013 - ACS Publications
Aspergillus niger is a cell factory for the production of enzymes. This fungus secretes
proteins in the central part and at the periphery of the colony. The sporulating zone of the�…

[HTML][HTML] Admixture Fine-Mapping in African Americans Implicates XAF1 as a Possible Sarcoidosis Risk Gene

AM Levin, MC Iannuzzi, CG Montgomery, S Trudeau…�- PloS one, 2014 - journals.plos.org
Sarcoidosis is a complex, multi-organ granulomatous disease with a likely genetic
component. West African ancestry confers a higher risk for sarcoidosis than European�…

Breast milk transforming growth factor β is associated with neonatal gut microbial composition

AR Sitarik, KR Bobbitt, SL Havstad…�- Journal of pediatric�…, 2017 - journals.lww.com
Methods: A total of 52 maternal-child pairs were drawn from a racially diverse birth cohort
based in Detroit, Michigan. Breast milk and neonatal stool specimens were collected at 1�…