Autistic traits in epilepsy models: Why, when and how?

J Vel�škov�, JL Silverman, M Benson…�- Epilepsy research, 2018 - Elsevier
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or
epileptiform activity are observed in a significant proportion of ASD patients. Current�…

Properties of place cell firing after damage to the visual cortex

V Paz‐Villagr�n, PP Lenck‐Santini…�- European Journal of�…, 2002 - Wiley Online Library
Hippocampal place cells were recorded while rats with lesions of the striate visual cortex
foraged for food pellets in a cylindrical arena. Compared to control rats, rats with striate�…

Cognitive and Behavioral Comorbidities in Epilepsy: The Treacherous Nature of Animal Models: TLE Models and Comorbidities

PP Lenck-Santini�- Epilepsy Currents, 2013 - journals.sagepub.com
TLE Models and Comorbidities and thereby constituted a valid model of TLE showed mild to
no spatial performance impairment. Recently, the same group used identical protocols (PILO�…

Postictal single‐cell firing patterns in the hippocampus

JL Zhou, PP Lenck‐Santini, GL Holmes�- Epilepsia, 2007 - Wiley Online Library
Purpose: Patients with epilepsy have varying degrees of postictal impairment including
confusion and amnesia. This impairment adds substantially to the disease burden of�…

Seizure-Induced Newborn Neurons Might Not be So Bad after All: Seizure-Induced Newborn Neurons

PP Lenck-Santini�- Epilepsy Currents, 2013 - journals.sagepub.com
To increase the normal rate of adult neurogenesis, the authors used the amygdala kindling
model of TLE, where electrical stimulations (99 stimulation sessions at a regimen of 3 per�…

Temporal coordination: A key to understand cognitive and behavioral deficits in epilepsy

PP Lenck-Santini…�- Neurobiology of the�…, 2022 - books.google.com
The Clave, is an asymmetric rhythmic pattern that constitutes the core of the rhythmic
organization of Afro-Cuban music such as Son Cubano, Salsa, Mambo, Rumba, or Afro�…

A test of the time estimation hypothesis of place cell goal-related activity

V Hok, PP Lenck-Santini, E Save…�- Journal of integrative�…, 2007 - World Scientific
Place cells are hippocampal pyramidal neurons that discharge strongly in relation to the rat's
location in the environment. We recently reported that many place cells recorded from rats�…

Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model

D Isaev, Q Zhao, JK Kleen, PP Lenck‐Santini…�- …, 2011 - Wiley Online Library
Interictal spikes have been implicated in epileptogenesis and cognitive dysfunction in
epilepsy. Unfortunately, antiepileptic drugs have shown poor efficacy in suppressing�…

[HTML][HTML] Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis

SP Flynn, S Barrier, RC Scott, PP Lenck-Santini…�- PLoS�…, 2015 - journals.plos.org
The dentate gyrus is considered to function as an inhibitory gate limiting excitatory input to
the hippocampus. Following status epilepticus (SE), this gating function is reduced and�…

Cognitive and behavioral comorbidities of epilepsy

JK Kleen, RC Scott, GL Holmes, PP Lenck‐Santini�- Epilepsia, 2010 - Wiley Online Library
Major comorbidities of epilepsy include cognitive impairment and behavioral dysfunction.
The type and degree of these comorbidities is dependent upon etiology, age�…