The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction
between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by�…

Lung dendritic cells (DCs) bridge innate and adaptive immunity, and depending on context,
they also induce a Th1, Th2, or Th17 response to optimally clear infectious threats�…

PGD 2 is the major mediator released by mast cells during allergic responses, and it acts
through two different receptors, the D prostanoid receptor 1 (DP1) and DP2, also known as�…

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus�…

Prostaglandins (PGs) can enhance or suppress inflammation by acting on different receptors
expressed by hematopoietic and nonhematopoietic cells. Prostaglandin D2 binds to the D�…

Adjuvants are vaccine additives that stimulate the immune system without having any
specific antigenic effect of itself. In this study we show that alum adjuvant induces the�…

Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to
inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining�…

To cite this article: Hammad H, Lambrecht BN. Dendritic cells and airway epithelial cells at
the interface between innate and adaptive immune responses. Allergy 2011; 66: 579–587�…

Peroxisome proliferator-activated receptors (PPARs) are activated by an array of
polyunsaturated fatty acid derivatives, oxidized fatty acids, and phospholipids and are�…

Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
shown high efficacy, but immunocompromised participants were excluded from controlled�…