OBJECTIVE—To determine the effects of exercise, without weight loss, on insulin sensitivity
(SI), postheparin plasma lipase activity (PHPL), intravenous fat clearance rate (K2), and�…

Pacific Islanders, American Indians or Alaska Natives, and Native Hawaiians. This
proportion will increase to nearly 40% over the next 2 decades. The prevalence of obesity�…

Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While�…

Background—The early response of C-reactive protein to initiation of a
hydroxymethylglutaryl coenzyme A reductase inhibitor (statin) is not known. The purpose of�…

Here we report the presence of hyperphagia, obesity and insulin resistance in knockout
mice deficient in IL-18 or IL-18 receptor, and in mice transgenic for expression of IL-18�…

Cells obtain FAs either from LPL-catalyzed hydrolysis of lipoprotein triglyceride or from
unesterified FFAs associated with albumin. LPL also influences uptake of esterified lipids�…

EXECUTIVE SUMMARY The Obesity Society (TOS) commissioned a panel of experts from
among its members to undertake a review of the issue of labeling obesity a disease and to�…

goals of 160 mg/dL (in individuals without coronary heart disease and with 2 risk factors) or
130 mg/dL (in individuals without coronary heart disease and with 2 risk factors) after having�…

resistance syndrome (IRS), a disorder characterized by hyperinsulinemia, lipoprotein
abnormalities, and premature CVD. 7 The IRS, also called the metabolic syndrome, typically�…

The purpose of this science advisory is to summarize the currently available data concerning
thiazolidinediones and cardiovascular risk, with a focus on ischemic heart disease (IHD)�…