Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms
Objective To investigate whether the motor and neuroprotective effects of adenosine A2A
receptor (A2AR) antagonists are mediated by distinct cell types in the 1‐methyl‐4‐phenyl‐1�…
receptor (A2AR) antagonists are mediated by distinct cell types in the 1‐methyl‐4‐phenyl‐1�…
[HTML][HTML] Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
DC-mediated NKT cell activation is critical in initiating the immune response following
kidney ischemia/reperfusion injury (IRI), which mimics human acute kidney injury (AKI)�…
kidney ischemia/reperfusion injury (IRI), which mimics human acute kidney injury (AKI)�…
Infarct-Sparing Effect of A2A-Adenosine Receptor Activation Is Due Primarily to Its Action on Lymphocytes
Z Yang, YJ Day, MC Toufektsian, SI Ramos…�- Circulation, 2005 - Am Heart Assoc
Background—A2A-adenosine receptor (A2AAR) activation on reperfusion after ischemia
reduces the size of myocardial infarction, but the mechanism of action has not been fully�…
reduces the size of myocardial infarction, but the mechanism of action has not been fully�…
Extracellular adenosine regulates naive T cell development and peripheral maintenance
Adenosine produced as a byproduct of metabolic activity is present in all tissues and
produces dose-dependent suppression of TCR signaling. Naive T cell maintenance�…
produces dose-dependent suppression of TCR signaling. Naive T cell maintenance�…
Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells
Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells
are necessary to comprehend its range of diverse and contradictory effects. In this study, we�…
are necessary to comprehend its range of diverse and contradictory effects. In this study, we�…
[HTML][HTML] RANTES mediates kidney ischemia reperfusion injury through a possible role of HIF-1α and LncRNA PRINS
TM Yu, K Palanisamy, KT Sun, YJ Day, KH Shu…�- Scientific reports, 2016 - nature.com
RANTES (Regulated on activation, normal T-cell expressed and secreted), recruits
circulating leukocytes and augments inflammatory responses in many clinical conditions�…
circulating leukocytes and augments inflammatory responses in many clinical conditions�…
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis
Z Gao, BS Li, YJ Day, J Linden�- Molecular pharmacology, 2001 - ASPET
Adenosine accumulates to high levels in inflamed or ischemic tissues and activates A3
adenosine receptors (ARs) on mast cells to trigger degranulation. Here we show that�…
adenosine receptors (ARs) on mast cells to trigger degranulation. Here we show that�…
A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury
YJ Day, Y Li, JM Rieger, SI Ramos…�- The Journal of�…, 2005 - journals.aai.org
Activation of the A 2A adenosine receptor (A 2A R) during reperfusion of various tissues has
been found to markedly reduce ischemia-reperfusion injury. In this study, we used bone�…
been found to markedly reduce ischemia-reperfusion injury. In this study, we used bone�…
A1 Adenosine Receptor Activation Promotes Angiogenesis and Release of VEGF From Monocytes
AN Clark, R Youkey, X Liu, L Jia, R Blatt…�- Circulation�…, 2007 - Am Heart Assoc
Adenosine is a proangiogenic purine nucleoside released from ischemic and hypoxic
tissues. Of the 4 adenosine receptor (AR) subtypes (A1, A2A, A2B, and A3), the A2 and A3�…
tissues. Of the 4 adenosine receptor (AR) subtypes (A1, A2A, A2B, and A3), the A2 and A3�…
Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice
YJ Day, JT Liou, CM Lee, YC Lin, CC Mao, AH Chou…�- PAIN�, 2014 - Elsevier
Abstract Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in
recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice�…
recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice�…