Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation
AE Abrahamsson, I Geron, J Gotlib…�- Proceedings of the�…, 2009 - National Acad Sciences
Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is
responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia�…
responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia�…
[HTML][HTML] SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature
AM Becker, KH Dao, BK Han, R Kornu, S Lakhanpal…�- PloS one, 2013 - journals.plos.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized
by defective immune tolerance combined with immune cell hyperactivity resulting in the�…
by defective immune tolerance combined with immune cell hyperactivity resulting in the�…
Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial
Background Trials of fluoxetine for recovery after stroke report conflicting results. The
Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral�…
Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral�…
[HTML][HTML] A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition
DJ Goff, A Sadarangani, HJ Chun, CL Barrett…�- Cell stem cell, 2013 - cell.com
Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia
(CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part�…
(CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part�…
Rapid evolution in response to high-temperature selection
AF Bennett, KM Dao, RE Lenski�- Nature, 1990 - nature.com
TEMPERATURE is an important environmental factor affecting all organisms1, 2, and there
is ample evidence from comparative physiology that species1, 3 and even conspecific�…
is ample evidence from comparative physiology that species1, 3 and even conspecific�…
Neurotoxicants Are in the Air: Convergence of Human, Animal, and In Vitro Studies on the Effects of Air Pollution on the Brain
LG Costa, TB Cole, J Coburn, YC Chang…�- BioMed research�…, 2014 - Wiley Online Library
In addition to increased morbidity and mortality caused by respiratory and cardiovascular
diseases, air pollution may also negatively affect the brain and contribute to central nervous�…
diseases, air pollution may also negatively affect the brain and contribute to central nervous�…
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia
The molecular etiology of human progenitor reprogramming into self-renewing leukemia
stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered�…
stem cells (LSC) has remained elusive. Although DNA sequencing has uncovered�…
[HTML][HTML] Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic�…
KK Dao, K Teigen, R Kopperud, E Hodneland…�- Journal of Biological�…, 2006 - ASBMB
The cAMP-dependent protein kinase (PKA I and II) and the cAMP-stimulated GDP exchange
factors (Epac1 and-2) are major cAMP effectors. The cAMP affinity of the PKA holoenzyme�…
factors (Epac1 and-2) are major cAMP effectors. The cAMP affinity of the PKA holoenzyme�…
A hardware evaluation of cache partitioning to improve utilization and energy-efficiency while preserving responsiveness
Computing workloads often contain a mix of interactive, latency-sensitive foreground
applications and recurring background computations. To guarantee responsiveness�…
applications and recurring background computations. To guarantee responsiveness�…
Age-related mutations and chronic myelomonocytic leukemia
Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy nearly confined to
the elderly. Previous studies to determine incidence and prognostic significance of somatic�…
the elderly. Previous studies to determine incidence and prognostic significance of somatic�…