This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease
(AD) by examining its clinical, pathological and biomarker changes to see whether APOE4�…

Music and ketamine are both known to affect therapeutic outcomes, but few studies have
investigated their co-administration. This scoping review describes the existing literature on�…

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple�…

Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger known to
orchestrate a myriad of cellular functions over a wide range of timescales. In the last 20�…

Neurological disorders can manifest with altered neurofluid dynamics in different
compartments of the central nervous system. These include alterations in cerebral blood�…

Recent longitudinal PET imaging studies have established methods to estimate the age at
which amyloid becomes abnormal at the level of the individual. Here we recontextualized�…

Objective Biomarkers of Alzheimer disease vary between groups of self‐identified Black and
White individuals in some studies. This study examined whether the relationships between�…

Breakdown of the neurovascular unit is associated with blood-brain barrier (BBB) leakiness
contributing to cognitive decline and disease pathology in the early stages of Alzheimer's�…

The multi-target stool DNA (mt-sDNA) test screens for colorectal cancer by analyzing DNA
methylation/mutation and hemoglobin markers to algorithmically derive a qualitative result. A�…

Neurovascular 4D-Flow MRI enables non-invasive evaluation of cerebral hemodynamics
including measures of cerebral blood flow (CBF), vessel pulsatility index (PI), and cerebral�…