This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease
(AD) by examining its clinical, pathological and biomarker changes to see whether APOE4�…

Normal and pathologic neurobiological processes influence brain morphology in
coordinated ways that give rise to patterns of structural covariance (PSC) across brain�…

Mitochondrial dysfunction can arise from genetic defects or environmental exposures and
impact a wide range of biological processes. Among these are metabolic pathways involved�…

Imaging studies of treatment-resistant depression (TRD) have examined brain activity,
structure, and metabolite concentrations to identify critical areas of investigation in TRD as�…

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple�…

Importance Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid
(Aβ) accumulation without symptoms. The duration of this phase differs greatly among�…

Music and ketamine are both known to affect therapeutic outcomes, but few studies have
investigated their co-administration. This scoping review describes the existing literature on�…

Cancer cells display persistent underlying chromosomal instability, with individual tumour
types intriguingly exhibiting characteristic subsets of whole, and subchromosomal�…

Objective Biomarkers of Alzheimer disease vary between groups of self‐identified Black and
White individuals in some studies. This study examined whether the relationships between�…

Background Characterizing cerebrovascular hemodynamics in older adults is important for
identifying disease and understanding normal neurovascular aging. Four-dimensional (4D)�…