[HTML][HTML] Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity
Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age�…
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age�…
Matrix cross-linking–mediated mechanotransduction promotes posttraumatic osteoarthritis
JH Kim, G Lee, Y Won, M Lee…�- Proceedings of the�…, 2015 - National Acad Sciences
Osteoarthritis (OA) is characterized by impairment of the load-bearing function of articular
cartilage. OA cartilage matrix undergoes extensive biophysical remodeling characterized by�…
cartilage. OA cartilage matrix undergoes extensive biophysical remodeling characterized by�…
[HTML][HTML] Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis
Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint
remodeling. The underlying molecular changes underpinning disease progression are�…
remodeling. The underlying molecular changes underpinning disease progression are�…
[HTML][HTML] Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
While young muscle is capable of restoring the original architecture of damaged myofibers,
aged muscle displays a markedly reduced regeneration. We show that expression of the�…
aged muscle displays a markedly reduced regeneration. We show that expression of the�…
[HTML][HTML] Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
M Varela-Eir�n, A Varela-V�zquez…�- Cell death &�…, 2018 - nature.com
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo�…
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo�…
[HTML][HTML] Differential aging of growth plate cartilage underlies differences in bone length and thus helps determine skeletal proportions
Bones at different anatomical locations vary dramatically in size. For example, human
femurs are 20-fold longer than the phalanges in the fingers and toes. The mechanisms�…
femurs are 20-fold longer than the phalanges in the fingers and toes. The mechanisms�…
[HTML][HTML] Molecular differentiation between osteophytic and articular cartilage–clues for a transient and permanent chondrocyte phenotype
K Gelse, AB Ekici, F Cipa, B Swoboda, HD Carl…�- Osteoarthritis and�…, 2012 - Elsevier
OBJECTIVE: To identify the molecular differences between the transient and permanent
chondrocyte phenotype in osteophytic and articular cartilage. METHODS: Total RNA was�…
chondrocyte phenotype in osteophytic and articular cartilage. METHODS: Total RNA was�…
Epigenetic mechanisms underlying the aging of articular cartilage and osteoarthritis
M Zhang, JL Theleman, KA Lygrisse, J Wang�- Gerontology, 2019 - karger.com
Aging is a progressive and complicated bioprocess with overall decline in physiological
function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older�…
function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older�…
Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis
M Varela-Eirin, J Loureiro, E Fonseca…�- Ageing research�…, 2018 - Elsevier
Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is�…
This prototypic degenerative condition of ageing is the most common form of arthritis and is�…
Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
Owing to population aging, the social impact of osteoarthritis (OA)—the most common
musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to�…
musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to�…