A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance�…

Background: Antidepressants are effective in the prevention of relapse after remission from
an acute depressive episode. It is unclear, however, to what degree duration of the�…

Background Antidepressant drugs can promote remission from acute depressive episodes.
Our aim was to establish how long such treatments should be continued to prevent relapse�…

Objective: This meta-analysis reviewed data on the efficacy and effective-ness of second-
generation antidepressants for preventing major depression relapse and recurrence during�…

A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults�…

Objective: Continuation therapy with antidepressants is recommended for depressed
patients who have responded to initial treatment. We quantified its efficacy in preventing�…

Bschor T, Baethge C. No evidence for switching the antidepressant: systematic review and
meta‐analysis of RCTs of a common therapeutic strategy. Objective: Switching�…

Early improvement of depressive symptoms during the first two weeks of antidepressant
treatment has been discussed to be a resilience signal predicting a later positive treatment�…

Objective: Nonresponders to antidepressant monotherapy during acute treatment of major
depression are often switched to a new antidepressant. The objective of this meta-analysis�…

A substantial proportion of the burden of depression arises from its recurrent nature. The risk
of relapse after antidepressant medication (ADM) discontinuation is high but not uniform�…