Background: Over the past few years, the profile of Helicobacter pylori infection has changed
in Japan. In particular, the relationship between H. pylori and gastric cancer has been�…

Enzymatic reactions play a fundamentally important role in controlling and performing most
life processes. 1-3 Thus, understanding how enzymes work has both fundamental and�…

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that
primarily involves the motor neuron system. Approximately 5-10% of ALS is familial�…

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta�…

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance�…

Gastric cancer is the third leading cause of cancer death worldwide. Early detection and
accurate diagnosis of mucosal cancer is desirable in order to achieve decreased mortality;�…

Dental erosion is a multifactorial condition. The consideration of chemical, biological and
behavioral factors is fundamental for its prevention and therapy. Among the biological�…

Diabetic nephropathy (DN), a severe microvascular complication frequently associated with
both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. The condition�…

Electrostatic energies provide what is perhaps the most effective tool for structure–function
correlation of biological molecules. This review considers the current state of simulations of�…

The development of polymer-clay nanocomposite materials, in which nanometer-thick layers
ofclay are dispersed in polymers, was first achieved about 15 years ago. Since then, the�…