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Gossard TR, Trotti LM, Videnovic A, St Louis EK.Gossard TR, et al.Neurotherapeutics. 2021 Jan;18(1):140-155. doi: 10.1007/s13311-021-01019-4. Epub 2021 Apr 20.Neurotherapeutics. 2021.PMID: 33880737Free PMC article.Review.
RLS may be primary (idiopathic) or secondary to pregnancy or a variety of systemic disorders, especially iron deficiency, and chronic renal insufficiency. Genetic predisposition with a family history is common. The pathogenesis of RLS remains unclear but is likely to invol …
RLS may be primary (idiopathic) or secondary to pregnancy or a variety of systemic disorders, especially iron deficiency, and chronic renal …
Manconi M, Garcia-Borreguero D, Schormair B, Videnovic A, Berger K, Ferri R, Dauvilliers Y.Manconi M, et al.Nat Rev Dis Primers. 2021 Nov 3;7(1):80. doi: 10.1038/s41572-021-00311-z.Nat Rev Dis Primers. 2021.PMID: 34732752Review.
RLS is considered to be a complex condition in which predisposing genetic factors, environmental factors and comorbidities contribute to the expression of the disorder. ...
RLS is considered to be a complex condition in which predisposing genetic factors, environmental factors and comorbidities contribute …
Nanayakkara B, Di Michiel J, Yee BJ.Nanayakkara B, et al.Aust J Gen Pract. 2023 Sep;52(9):615-621. doi: 10.31128/AJGP-02-23-6722.Aust J Gen Pract. 2023.PMID: 37666782Free article.
DISCUSSION: RLS is a clinical diagnosis, although mimics exist. Brain iron deficiency, dopaminergic dysfunction and genetics underpin the poorly understood pathophysiology of this common condition. ...
DISCUSSION: RLS is a clinical diagnosis, although mimics exist. Brain iron deficiency, dopaminergic dysfunction and genetics underpin …
Symptoms frequency, age at RLS onset, severity, familial history and consequences of RLS vary widely between patients. A genetic susceptibility, iron deficiency, dopamine deregulation, and possible hypo-adenosinergic state may play a role in the pathophysiology of RLS. ...
Symptoms frequency, age at RLS onset, severity, familial history and consequences of RLS vary widely between patients. A genetic susc …
Cederberg KLJ, Silvestri R, Walters AS.Cederberg KLJ, et al.Tremor Other Hyperkinet Mov (N Y). 2023 Apr 6;13:12. doi: 10.5334/tohm.741. eCollection 2023.Tremor Other Hyperkinet Mov (N Y). 2023.PMID: 37034443Free PMC article.Review.
We review the prevalence of vitamin D deficiency in RLS as well as the evidence for the use of vitamin D supplementation in RLS management. We further examine the literature for proteomic and genetic evidence of a role for vitamin D in the pathogenesis of RLS. ...
We review the prevalence of vitamin D deficiency in RLS as well as the evidence for the use of vitamin D supplementation in RLS management. …
Lv Q, Wang X, Asakawa T, Wang XP.Lv Q, et al.Curr Neuropharmacol. 2021;19(3):372-382. doi: 10.2174/1570159X19666201230150127.Curr Neuropharmacol. 2021.PMID: 33380302Free PMC article.Review.
Liu Z, Guan R, Pan L.Liu Z, et al.Medicine (Baltimore). 2022 Dec 16;101(50):e32324. doi: 10.1097/MD.0000000000032324.Medicine (Baltimore). 2022.PMID: 36550837Free PMC article.Review.
The pathogenesis of RLS remains unknown, and recent pathophysiological developments have shown the contribution of various genetic markers, neurotransmitter dysfunction, and iron deficiency to the disease, as well as other unidentified contributing mechanisms, particularly …
The pathogenesis of RLS remains unknown, and recent pathophysiological developments have shown the contribution of various genetic ma …
Earley CJ, Jones BC, Ferré S.Earley CJ, et al.Exp Neurol. 2022 Oct;356:114158. doi: 10.1016/j.expneurol.2022.114158. Epub 2022 Jun 30.Exp Neurol. 2022.PMID: 35779614Free PMC article.Review.
Finally, we will present arguments for the utility of recombinant inbred mouse strains that demonstrate natural variation in brain iron, to explore the genetic basis of altered brain iron homeostasis as a model to understand why in idiopathic RLS there can exist a BID desp …
Finally, we will present arguments for the utility of recombinant inbred mouse strains that demonstrate natural variation in brain iron, to …
