SM-Youtube

Year	Number of Results
1945	11
1946	44
1947	36
1948	30
1949	39
1950	23
1951	31
1952	18
1953	33
1954	20
1955	35
1956	26
1957	25
1958	40
1959	39
1960	38
1961	47
1962	80
1963	178
1964	245
1965	161
1966	158
1967	197
1968	202
1969	236
1970	225
1971	227
1972	272
1973	230
1974	202
1975	187
1976	152
1977	151
1978	163
1979	141
1980	148
1981	182
1982	146
1983	141
1984	159
1985	155
1986	126
1987	95
1988	108
1989	121
1990	147
1991	97
1992	108
1993	106
1994	86
1995	96
1996	100
1997	100
1998	128
1999	144
2000	122
2001	129
2002	68
2003	55
2004	56
2005	60
2006	56
2007	55
2008	56
2009	52
2010	57
2011	52
2012	56
2013	67
2014	61
2015	67
2016	54
2017	63
2018	70
2019	50
2020	65
2021	60
2022	84
2023	63
2024	25

Year

Number of Results

1945

1946

1947

1948

1949

1950

1951

1952

1953

1954

1955

1956

1957

1958

1959

1960

1961

1962

1963

178

1964

245

1965

161

1966

158

1967

197

1968

202

1969

236

1970

225

1971

227

1972

272

1973

230

1974

202

1975

187

1976

152

1977

151

1978

163

1979

141

1980

148

1981

182

1982

146

1983

141

1984

159

1985

155

1986

126

1987

1988

108

1989

121

1990

147

1991

1992

108

1993

106

1994

1995

1996

100

1997

100

1998

128

1999

144

2000

122

2001

129

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

2024

Page 1

The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.

Jayawardena R, Majeed S, Sooriyaarachchi P, Abeywarne U, Ranaweera P. Jayawardena R, et al. Arch Gynecol Obstet. 2023 Oct;308(4):1075-1084. doi: 10.1007/s00404-023-06925-w. Epub 2023 Jan 31. Arch Gynecol Obstet. 2023. PMID: 36719452 Review.

Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events: A systematic review.

Romoli M, Perucca E, Sen A. Romoli M, et al. Epilepsy Behav. 2020 Feb;103(Pt A):106861. doi: 10.1016/j.yebeh.2019.106861. Epub 2020 Jan 6. Epilepsy Behav. 2020. PMID: 31917143

Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity.

Hadtstein F, Vrolijk M. Hadtstein F, et al. Adv Nutr. 2021 Oct 1;12(5):1911-1929. doi: 10.1093/advances/nmab033. Adv Nutr. 2021. PMID: 33912895 Free PMC article. Review.

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection.

Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, Yao H, Song N, Ding X, Ding J, Xiao M, Hu G. Wei Y, et al. Nat Commun. 2020 Feb 18;11(1):941. doi: 10.1038/s41467-020-14788-x. Nat Commun. 2020. PMID: 32071304 Free PMC article.

Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency.

Coughlin CR 2nd, Tseng LA, Abdenur JE, Ashmore C, Boemer F, Bok LA, Boyer M, Buhas D, Clayton PT, Das A, Dekker H, Evangeliou A, Feillet F, Footitt EJ, Gospe SM Jr, Hartmann H, Kara M, Kristensen E, Lee J, Lilje R, Longo N, Lunsing RJ, Mills P, Papadopoulou MT, Pearl PL, Piazzon F, Plecko B, Saini AG, Santra S, Sjarif DR, Stockler-Ipsiroglu S, Striano P, Van Hove JLK, Verhoeven-Duif NM, Wijburg FA, Zuberi SM, van Karnebeek CDM. Coughlin CR 2nd, et al. J Inherit Metab Dis. 2021 Jan;44(1):178-192. doi: 10.1002/jimd.12332. Epub 2020 Dec 1. J Inherit Metab Dis. 2021. PMID: 33200442

A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP).

Sharifzadeh F, Kashanian M, Koohpayehzadeh J, Rezaian F, Sheikhansari N, Eshraghi N. Sharifzadeh F, et al. J Matern Fetal Neonatal Med. 2018 Oct;31(19):2509-2514. doi: 10.1080/14767058.2017.1344965. Epub 2017 Jul 7. J Matern Fetal Neonatal Med. 2018. PMID: 28629250 Clinical Trial.

The effectiveness of citrates and pyridoxine in the treatment of kidney stones.

Ene MA, Geavlete PA, Simeanu CE, Bulai CA, Ene CV, Geavlete BF. Ene MA, et al. J Med Life. 2023 Jun;16(6):856-861. doi: 10.25122/jml-2023-0234. J Med Life. 2023. PMID: 37675156 Free PMC article. Review.

Chemical Modifications of Pyridoxine for Biological Applications: An Overview.

Pawar R, Chaudhran P, Pandey D, Sharma A. Pawar R, et al. Curr Top Med Chem. 2023;23(2):98-113. doi: 10.2174/1568026623666221208125203. Curr Top Med Chem. 2023. PMID: 36503471 Review.

Pearls & Oy-sters: Delayed Response to Pyridoxine in Pyridoxine-Dependent Epilepsy.

Fortin O, Christoffel K, Kousa Y, Miller I, Leon E, Donoho K, Mulkey SB, Anwar T. Fortin O, et al. Neurology. 2023 Oct 31;101(18):e1828-e1832. doi: 10.1212/WNL.0000000000207829. Epub 2023 Aug 14. Neurology. 2023. PMID: 37580162

Chemical glucosylation of pyridoxine.

Bachmann T, Rychlik M. Bachmann T, et al. Carbohydr Res. 2020 Mar;489:107929. doi: 10.1016/j.carres.2020.107929. Epub 2020 Jan 30. Carbohydr Res. 2020. PMID: 32044534

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