SM-Youtube

Year	Number of Results
1997	11
1998	50
1999	73
2000	67
2001	63
2002	75
2003	97
2004	96
2005	135
2006	198
2007	218
2008	275
2009	331
2010	389
2011	475
2012	584
2013	745
2014	786
2015	822
2016	788
2017	814
2018	785
2019	854
2020	875
2021	809
2022	907
2023	716
2024	358

1

Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

Choi S, Houdek X, Anderson RA. Choi S, et al. Adv Biol Regul. 2018 May;68:31-38. doi: 10.1016/j.jbior.2018.02.003. Epub 2018 Feb 8. Adv Biol Regul. 2018. PMID: 29472147 Free PMC article. Review.

2

Breast cancer: an up-to-date review and future perspectives.

Hong R, Xu B. Hong R, et al. Cancer Commun (Lond). 2022 Oct;42(10):913-936. doi: 10.1002/cac2.12358. Epub 2022 Sep 8. Cancer Commun (Lond). 2022. PMID: 36074908 Free PMC article. Review.

3

Distinct longevity mechanisms across and within species and their association with aging.

Tyshkovskiy A, Ma S, Shindyapina AV, Tikhonov S, Lee SG, Bozaykut P, Castro JP, Seluanov A, Schork NJ, Gorbunova V, Dmitriev SE, Miller RA, Gladyshev VN. Tyshkovskiy A, et al. Cell. 2023 Jun 22;186(13):2929-2949.e20. doi: 10.1016/j.cell.2023.05.002. Epub 2023 Jun 3. Cell. 2023. PMID: 37269831 Free PMC article.

4

A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations.

Canaud G, Hammill AM, Adams D, Vikkula M, Keppler-Noreuil KM. Canaud G, et al. Orphanet J Rare Dis. 2021 Jul 8;16(1):306. doi: 10.1186/s13023-021-01929-8. Orphanet J Rare Dis. 2021. PMID: 34238334 Free PMC article. Review.

5

Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns.

Philippon H, Brochier-Armanet C, Perrière G. Philippon H, et al. BMC Evol Biol. 2015 Oct 19;15:226. doi: 10.1186/s12862-015-0498-7. BMC Evol Biol. 2015. PMID: 26482564 Free PMC article.

6

Keppler-Noreuil KM, Rios JJ, Parker VE, Semple RK, Lindhurst MJ, Sapp JC, Alomari A, Ezaki M, Dobyns W, Biesecker LG. Keppler-Noreuil KM, et al. Am J Med Genet A. 2015 Feb;167A(2):287-95. doi: 10.1002/ajmg.a.36836. Epub 2014 Dec 31. Am J Med Genet A. 2015. PMID: 25557259 Free PMC article.

7

CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.

Gong Z, Zhu J, Chen J, Feng F, Zhang H, Zhang Z, Song C, Liang K, Yang S, Fan S, Fang X, Shen S. Gong Z, et al. Nat Commun. 2023 Aug 28;14(1):5242. doi: 10.1038/s41467-023-40975-7. Nat Commun. 2023. PMID: 37640697 Free PMC article.

8

Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis.

Alkhoury C, Henneman NF, Petrenko V, Shibayama Y, Segaloni A, Gadault A, Nemazanyy I, Le Guillou E, Wolide AD, Antoniadou K, Tong X, Tamaru T, Ozawa T, Girard M, Hnia K, Lutter D, Dibner C, Panasyuk G. Alkhoury C, et al. Nat Cell Biol. 2023 Jul;25(7):975-988. doi: 10.1038/s41556-023-01171-3. Epub 2023 Jul 6. Nat Cell Biol. 2023. PMID: 37414850 Free PMC article.

9

Outcome and molecular landscape of patients with PIK3CA-mutated metastatic breast cancer.

Mosele F, Stefanovska B, Lusque A, Tran Dien A, Garberis I, Droin N, Le Tourneau C, Sablin MP, Lacroix L, Enrico D, Miran I, Jovelet C, Bièche I, Soria JC, Bertucci F, Bonnefoi H, Campone M, Dalenc F, Bachelot T, Jacquet A, Jimenez M, André F. Mosele F, et al. Ann Oncol. 2020 Mar;31(3):377-386. doi: 10.1016/j.annonc.2019.11.006. Epub 2020 Jan 24. Ann Oncol. 2020. PMID: 32067679 Free article.

10

Alpelisib for treatment of patients with PIK3CA-related overgrowth spectrum (PROS).

Canaud G, Lopez Gutierrez JC, Irvine AD, Vabres P, Hansford JR, Ankrah N, Branle F, Papadimitriou A, Ridolfi A, O'Connell P, Turner S, Adams DM. Canaud G, et al. Genet Med. 2023 Dec;25(12):100969. doi: 10.1016/j.gim.2023.100969. Epub 2023 Aug 24. Genet Med. 2023. PMID: 37634128

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