SM-Youtube

1

The intrinsic substrate specificity of the human tyrosine kinome.

Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Yaron-Barir TM, et al. Among authors: blenis j. Nature. 2024 May;629(8014):1174-1181. doi: 10.1038/s41586-024-07407-y. Epub 2024 May 8. Nature. 2024. PMID: 38720073 Free PMC article.

2

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.

Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. Chung J, et al. Among authors: blenis j. Nature. 1994 Jul 7;370(6484):71-5. doi: 10.1038/370071a0. Nature. 1994. PMID: 8015612

3

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Manning BD, et al. Among authors: blenis j. Mol Cell. 2002 Jul;10(1):151-62. doi: 10.1016/s1097-2765(02)00568-3. Mol Cell. 2002. PMID: 12150915 Free article.

4

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tee AR, et al. Among authors: blenis j. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. doi: 10.1073/pnas.202476899. Epub 2002 Sep 23. Proc Natl Acad Sci U S A. 2002. PMID: 12271141 Free PMC article.

5

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tee AR, et al. Among authors: blenis j. Curr Biol. 2003 Aug 5;13(15):1259-68. doi: 10.1016/s0960-9822(03)00506-2. Curr Biol. 2003. PMID: 12906785 Free article.

6

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.

Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Choo AY, et al. Among authors: blenis j. Mol Cell. 2010 May 28;38(4):487-99. doi: 10.1016/j.molcel.2010.05.007. Mol Cell. 2010. PMID: 20513425 Free PMC article.

7

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J. Yu Y, et al. Among authors: blenis j. Science. 2011 Jun 10;332(6035):1322-6. doi: 10.1126/science.1199484. Science. 2011. PMID: 21659605 Free PMC article.

8

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J. Kim SG, et al. Among authors: blenis j. Mol Cell. 2013 Jan 10;49(1):172-85. doi: 10.1016/j.molcel.2012.10.003. Epub 2012 Nov 8. Mol Cell. 2013. PMID: 23142078 Free PMC article.

9

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Galan JA, et al. Among authors: blenis j. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27. doi: 10.1073/pnas.1405601111. Epub 2014 Jul 7. Proc Natl Acad Sci U S A. 2014. PMID: 25002506 Free PMC article.

10

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. Liu P, et al. Among authors: blenis j. Cancer Discov. 2015 Nov;5(11):1194-209. doi: 10.1158/2159-8290.CD-15-0460. Epub 2015 Aug 20. Cancer Discov. 2015. PMID: 26293922 Free PMC article.

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