SM-Youtube

1

The intrinsic substrate specificity of the human tyrosine kinome.

Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Yaron-Barir TM, et al. Among authors: bedford mt. Nature. 2024 May;629(8014):1174-1181. doi: 10.1038/s41586-024-07407-y. Epub 2024 May 8. Nature. 2024. PMID: 38720073 Free PMC article.

2

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X. Zhang X, et al. Among authors: bedford mt. Nat Commun. 2016 Mar 10;7:10810. doi: 10.1038/ncomms10810. Nat Commun. 2016. PMID: 26960573 Free PMC article.

3

Protein domain microarrays as a platform to decipher signaling pathways and the histone code.

Chen J, Sagum C, Bedford MT. Chen J, et al. Among authors: bedford mt. Methods. 2020 Dec 1;184:4-12. doi: 10.1016/j.ymeth.2019.08.007. Epub 2019 Aug 23. Methods. 2020. PMID: 31449908 Review.

4

A novel pro-Arg motif recognized by WW domains.

Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. Bedford MT, et al. J Biol Chem. 2000 Apr 7;275(14):10359-69. doi: 10.1074/jbc.275.14.10359. J Biol Chem. 2000. PMID: 10744724 Free article.

5

Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions.

Chen J, Horton J, Sagum C, Zhou J, Cheng X, Bedford MT. Chen J, et al. Among authors: bedford mt. Biochem J. 2021 May 28;478(10):1943-1958. doi: 10.1042/BCJ20210203. Biochem J. 2021. PMID: 33969871 Free PMC article.

6

Developing Spindlin1 small-molecule inhibitors by using protein microarrays.

Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Sbardella G, Bedford MT. Bae N, et al. Among authors: bedford mt. Nat Chem Biol. 2017 Jul;13(7):750-756. doi: 10.1038/nchembio.2377. Epub 2017 May 15. Nat Chem Biol. 2017. PMID: 28504676 Free PMC article.

7

Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.

Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Bedford MT, et al. J Biol Chem. 2000 May 26;275(21):16030-6. doi: 10.1074/jbc.M909368199. J Biol Chem. 2000. PMID: 10748127 Free article.

8

Systematic identification of methyllysine-driven interactions for histone and nonhistone targets.

Liu H, Galka M, Iberg A, Wang Z, Li L, Voss C, Jiang X, Lajoie G, Huang Z, Bedford MT, Li SS. Liu H, et al. Among authors: bedford mt. J Proteome Res. 2010 Nov 5;9(11):5827-36. doi: 10.1021/pr100597b. Epub 2010 Oct 1. J Proteome Res. 2010. PMID: 20836566

9

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A. Levy-Apter E, et al. Among authors: bedford mt. J Biol Chem. 2014 Dec 26;289(52):36048-58. doi: 10.1074/jbc.M114.603548. Epub 2014 Nov 7. J Biol Chem. 2014. PMID: 25381250 Free PMC article.

10

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.

Yu D, Horton JR, Yang J, Hajian T, Vedadi M, Sagum CA, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Yu D, et al. Among authors: bedford mt. Nucleic Acids Res. 2021 Nov 18;49(20):11629-11642. doi: 10.1093/nar/gkab460. Nucleic Acids Res. 2021. PMID: 34086966 Free PMC article.

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