SM-Youtube

1

The ribotoxic stress response drives UV-mediated cell death.

Sinha NK, McKenney C, Yeow ZY, Li JJ, Nam KH, Yaron-Barir TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Regot S, Green R. Sinha NK, et al. Among authors: regot s. Cell. 2024 Jul 11;187(14):3652-3670.e40. doi: 10.1016/j.cell.2024.05.018. Epub 2024 Jun 5. Cell. 2024. PMID: 38843833 Free article.

2

CDK4/6 activity is required during G₂ arrest to prevent stress-induced endoreplication.

McKenney C, Lendner Y, Guerrero Zuniga A, Sinha N, Veresko B, Aikin TJ, Regot S. McKenney C, et al. Among authors: regot s. Science. 2024 May 3;384(6695):eadi2421. doi: 10.1126/science.adi2421. Epub 2024 May 3. Science. 2024. PMID: 38696576

3

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.

Xin T, Gallini S, Wei H, Gonzalez DG, Matte-Martone C, Machida H, Fujiwara H, Pasolli HA, Suozzi KC, Gonzalez LE, Regot S, Greco V. Xin T, et al. Among authors: regot s. Nat Cell Biol. 2024 Jun;26(6):859-867. doi: 10.1038/s41556-024-01413-y. Epub 2024 Apr 30. Nat Cell Biol. 2024. PMID: 38689013

4

Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication.

Guerrero Zuniga A, Aikin TJ, McKenney C, Lendner Y, Phung A, Hook PW, Meltzer A, Timp W, Regot S. Guerrero Zuniga A, et al. Among authors: regot s. Dev Cell. 2024 Jul 8;59(13):1724-1736.e4. doi: 10.1016/j.devcel.2024.03.032. Epub 2024 Apr 18. Dev Cell. 2024. PMID: 38640927

5

Organ function is preserved despite reorganization of niche architecture in the hair follicle.

Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S, Gonzalez LE, Xin T, Greco V. Wei H, et al. Among authors: regot s. Cell Stem Cell. 2023 Jul 6;30(7):962-972.e6. doi: 10.1016/j.stem.2023.06.003. Cell Stem Cell. 2023. PMID: 37419106 Free PMC article.

6

Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate.

Peterson AF, Ingram K, Huang EJ, Parksong J, McKenney C, Bever GS, Regot S. Peterson AF, et al. Among authors: regot s. Cell Syst. 2022 Nov 16;13(11):885-894.e4. doi: 10.1016/j.cels.2022.10.003. Epub 2022 Nov 9. Cell Syst. 2022. PMID: 36356576 Free PMC article.

7

CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.

Wang Q, Hernández-Ochoa EO, Viswanathan MC, Blum ID, Do DC, Granger JM, Murphy KR, Wei AC, Aja S, Liu N, Antonescu CM, Florea LD, Talbot CC Jr, Mohr D, Wagner KR, Regot S, Lovering RM, Gao P, Bianchet MA, Wu MN, Cammarato A, Schneider MF, Bever GS, Anderson ME. Wang Q, et al. Among authors: regot s. Nat Commun. 2021 May 26;12(1):3175. doi: 10.1038/s41467-021-23549-3. Nat Commun. 2021. PMID: 34039988 Free PMC article.

8

3D time-lapse microscopy paired with endpoint lineage analysis in mouse blastocysts.

Pokrass MJ, Regot S. Pokrass MJ, et al. Among authors: regot s. STAR Protoc. 2021 Apr 8;2(2):100446. doi: 10.1016/j.xpro.2021.100446. eCollection 2021 Jun 18. STAR Protoc. 2021. PMID: 33899025 Free PMC article.

9

Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level.

Clark HR, McKenney C, Livingston NM, Gershman A, Sajjan S, Chan IS, Ewald AJ, Timp W, Wu B, Singh A, Regot S. Clark HR, et al. Among authors: regot s. Nat Commun. 2021 Mar 23;12(1):1836. doi: 10.1038/s41467-021-22070-x. Nat Commun. 2021. PMID: 33758175 Free PMC article.

10

Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo.

Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Pokrass MJ, et al. Among authors: regot s. Dev Cell. 2020 Nov 9;55(3):328-340.e5. doi: 10.1016/j.devcel.2020.09.013. Epub 2020 Oct 21. Dev Cell. 2020. PMID: 33091369 Free PMC article.

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