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Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma.
Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH , Stanger BZ.
Kim IK, et al. Among authors: vonderheide rh .
Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7.
Nat Commun. 2024.
PMID: 38378697
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EMT and dissemination precede pancreatic tumor formation.
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH , Leach SD, Stanger BZ.
Rhim AD, et al. Among authors: vonderheide rh .
Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025.
Cell. 2012.
PMID: 22265420
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CD40 immunotherapy for pancreatic cancer.
Vonderheide RH , Bajor DL, Winograd R, Evans RA, Bayne LJ, Beatty GL.
Vonderheide RH , et al.
Cancer Immunol Immunother. 2013 May;62(5):949-54. doi: 10.1007/s00262-013-1427-5. Epub 2013 Apr 16.
Cancer Immunol Immunother. 2013.
PMID: 23589109
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Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma.
Winograd R, Byrne KT, Evans RA, Odorizzi PM, Meyer AR, Bajor DL, Clendenin C, Stanger BZ, Furth EE, Wherry EJ, Vonderheide RH.
Winograd R, et al. Among authors: vonderheide rh .
Cancer Immunol Res. 2015 Apr;3(4):399-411. doi: 10.1158/2326-6066.CIR-14-0215. Epub 2015 Feb 12.
Cancer Immunol Res. 2015.
PMID: 25678581
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Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6C(low) F4/80(+) Extratumoral Macrophages.
Beatty GL, Winograd R, Evans RA, Long KB, Luque SL, Lee JW, Clendenin C, Gladney WL, Knoblock DM, Guirnalda PD, Vonderheide RH.
Beatty GL, et al. Among authors: vonderheide rh .
Gastroenterology. 2015 Jul;149(1):201-10. doi: 10.1053/j.gastro.2015.04.010. Epub 2015 Apr 14.
Gastroenterology. 2015.
PMID: 25888329
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Metastatic progression is associated with dynamic changes in the local microenvironment.
Aiello NM, Bajor DL, Norgard RJ, Sahmoud A, Bhagwat N, Pham MN, Cornish TC, Iacobuzio-Donahue CA, Vonderheide RH , Stanger BZ.
Aiello NM, et al. Among authors: vonderheide rh .
Nat Commun. 2016 Sep 15;7:12819. doi: 10.1038/ncomms12819.
Nat Commun. 2016.
PMID: 27628423
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Lack of immunoediting in murine pancreatic cancer reversed with neoantigen.
Evans RA, Diamond MS, Rech AJ, Chao T, Richardson MW, Lin JH, Bajor DL, Byrne KT, Stanger BZ, Riley JL, Markosyan N, Winograd R, Vonderheide RH.
Evans RA, et al. Among authors: vonderheide rh .
JCI Insight. 2016 Sep 8;1(14):e88328. doi: 10.1172/jci.insight.88328.
JCI Insight. 2016.
PMID: 27642636
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