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A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.
O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED. O'Neill BT, et al. Among authors: zaha vg. Cell Metab. 2007 Oct;6(4):294-306. doi: 10.1016/j.cmet.2007.09.001. Cell Metab. 2007. PMID: 17908558 Free PMC article.
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED. Boudina S, et al. Among authors: zaha vg. Circulation. 2009 Mar 10;119(9):1272-83. doi: 10.1161/CIRCULATIONAHA.108.792101. Epub 2009 Feb 23. Circulation. 2009. PMID: 19237663 Free PMC article.
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.
Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. Riehle C, et al. Among authors: zaha vg. Circ Res. 2011 Sep 16;109(7):783-93. doi: 10.1161/CIRCRESAHA.111.243964. Epub 2011 Jul 28. Circ Res. 2011. PMID: 21799152 Free PMC article.
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. Lelliott CJ, et al. Among authors: zaha vg. PLoS Biol. 2006 Nov;4(11):e369. doi: 10.1371/journal.pbio.0040369. PLoS Biol. 2006. PMID: 17090215 Free PMC article.
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.
Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME. Durgan DJ, et al. Among authors: zaha vg. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2480-97. doi: 10.1152/ajpheart.01344.2005. Epub 2006 Jan 20. Am J Physiol Heart Circ Physiol. 2006. PMID: 16428347 Free article.
79 results