Reaction time responding in rats
- PMID: 9809315
- DOI: 10.1016/s0149-7634(98)00013-x
Reaction time responding in rats
Abstract
The use of reaction time has a great tradition in the field of human information processing research. In animal research the use of reaction time test paradigms is mainly limited to two research fields: the role of the striatum in movement initiation; and aging. It was discussed that reaction time responding can be regarded as "single behavior", this term was used to indicate that only one behavioral category is measured, allowing a better analysis of brain-behavior relationships. Reaction time studies investigating the role of the striatum in motor functions revealed that the initiation of a behavioral response is dependent on the interaction of different neurotransmitters (viz. dopamine, glutamate, GABA). Studies in which lesions were made in different brain structures suggested that motor initiation is dependent on defined brain structures (e.g. medialldorsal striatum, prefrontal cortex). It was concluded that the use of reaction time measures can indeed be a powerful tool in studying brain-behavior relationships. However, there are some methodological constraints with respect to the assessment of reaction time in rats, as was tried to exemplify by the experiments described in the present paper. On the one hand one should try to control for behavioral characteristics of rats that may affect the validity of the parameter reaction time. On the other hand, the mean value of reaction time should be in the range of what has been reported in man. Although these criteria were not always met in several studies, it was concluded that reaction time can be validly assessed in rats. Finally, it was discussed that the use of reaction time may go beyond studies that investigate the role of the basal ganglia in motor output. Since response latency is a direct measure of information processing this parameter may provide insight into basic elements of cognition. Based on the significance of reaction times in human studies the use of this dependent variable in rats may provide a fruitful approach in studying brain-behavior relationships in cognitive functions.
Similar articles
-
Dopamine receptor antagonists reverse amphetamine-induced behavioral alteration on a differential reinforcement for low-rate (DRL) operant task in the rat.Chin J Physiol. 2007 Apr 30;50(2):77-88. Chin J Physiol. 2007. PMID: 17608145
-
Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamine.Behav Brain Res. 2010 Dec 25;214(2):216-24. doi: 10.1016/j.bbr.2010.05.027. Epub 2010 May 24. Behav Brain Res. 2010. PMID: 20580749
-
Dopamine and complex sensorimotor integration: further studies in a conditioned motor task in the rat.Neuroscience. 1995 Mar;65(2):375-84. doi: 10.1016/0306-4522(94)00498-t. Neuroscience. 1995. PMID: 7777155
-
The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry.Psychopharmacology (Berl). 2002 Oct;163(3-4):362-80. doi: 10.1007/s00213-002-1154-7. Epub 2002 Aug 9. Psychopharmacology (Berl). 2002. PMID: 12373437 Review.
-
Pharmacology and physiology of stereotyped behavior.J Psychiatr Res. 1974;11:1-10. doi: 10.1016/0022-3956(74)90062-4. J Psychiatr Res. 1974. PMID: 4218871 Review. No abstract available.
Cited by
-
Strategically managing learning during perceptual decision making.Elife. 2023 Feb 14;12:e64978. doi: 10.7554/eLife.64978. Elife. 2023. PMID: 36786427 Free PMC article.
-
Identifying control ensembles for information processing within the cortico-basal ganglia-thalamic circuit.PLoS Comput Biol. 2022 Jun 23;18(6):e1010255. doi: 10.1371/journal.pcbi.1010255. eCollection 2022 Jun. PLoS Comput Biol. 2022. PMID: 35737720 Free PMC article.
-
Impacts of a perinatal exposure to manganese coupled with maternal stress in rats: Learning, memory and attentional function in exposed offspring.Neurotoxicol Teratol. 2022 May-Jun;91:107077. doi: 10.1016/j.ntt.2022.107077. Epub 2022 Feb 18. Neurotoxicol Teratol. 2022. PMID: 35189282 Free PMC article.
-
Knockout serotonin transporter in rats moderates outcome and stimulus generalization.Transl Psychiatry. 2021 Jan 7;11(1):25. doi: 10.1038/s41398-020-01162-0. Transl Psychiatry. 2021. PMID: 33414390 Free PMC article.
-
Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action.Curr Top Behav Neurosci. 2016;27:199-230. doi: 10.1007/7854_2015_382. Curr Top Behav Neurosci. 2016. PMID: 26276036 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous