A dual pathway model of daily stressor effects on rheumatoid arthritis
- PMID: 9603691
- DOI: 10.1007/BF02883333
A dual pathway model of daily stressor effects on rheumatoid arthritis
Abstract
This study evaluated the initial promise of a dual-pathway conceptual model linking daily event stressors to rheumatoid arthritis (RA) disease activity through changes in immune system activation and mood. Fifty individuals, who were studied on five occasions two weeks apart, reported daily event stressors on the Daily Life Experience Checklist, daily mood on an abbreviated version of the Profile of Mood States-B, and daily joint pain on the Rapid Assessment of Disease Activity in Rheumatology. Serial clinical examinations comprised ratings of joint tenderness and swelling, and blood drawn during exams was analyzed for sedimentation rate (an indicator of systemic inflammation) and soluble interleukin-2 receptors (a marker of immune system activation known to correlate with RA disease activity). Across-person analyses failed to establish links from daily event stressors to either disease activity or composites of joint pain and joint inflammation when associations were adjusted for the effect of neuroticism on self-report measures. Pooled within-person analyses, however, were generally consistent with the relations predicted by the dual-pathway model. Increases in daily event stressors during the week preceding each clinical exam were associated with increased joint pain (regardless of changes in mood). At the same time, increased daily stressors were indirectly associated with decreased joint inflammation through reduction in levels of soluble interleukin-2 receptors. The dual-pathway model, which may be limited to short-term psychological and psychoimmunologic processes, underscores the importance of distinguishing potentially opposing effects of stress on pain versus inflammation in individuals with rheumatoid arthritis.
Similar articles
-
Examination of changes in interpersonal stress as a factor in disease exacerbations among women with rheumatoid arthritis.Ann Behav Med. 1997 Summer;19(3):279-86. doi: 10.1007/BF02892292. Ann Behav Med. 1997. PMID: 9603702
-
Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease activity in rheumatoid arthritis.Arthritis Rheum. 1993 Feb;36(2):199-203. doi: 10.1002/art.1780360209. Arthritis Rheum. 1993. PMID: 8431208
-
Differential relationships between stress and disease activity for immunologically distinct subgroups of people with rheumatoid arthritis.J Abnorm Psychol. 1994 May;103(2):251-8. doi: 10.1037//0021-843x.103.2.251. J Abnorm Psychol. 1994. PMID: 8040494
-
Stress and rheumatoid arthritis: an integrative review.Arthritis Care Res. 1998 Apr;11(2):135-45. doi: 10.1002/art.1790110209. Arthritis Care Res. 1998. PMID: 9668736 Review. No abstract available.
-
Health psychology: psychological factors and physical disease from the perspective of human psychoneuroimmunology.Annu Rev Psychol. 1996;47:113-42. doi: 10.1146/annurev.psych.47.1.113. Annu Rev Psychol. 1996. PMID: 8624135 Review.
Cited by
-
Epigenetic aging and perceived psychological stress in old age.Transl Psychiatry. 2022 Sep 26;12(1):410. doi: 10.1038/s41398-022-02181-9. Transl Psychiatry. 2022. PMID: 36163242 Free PMC article.
-
A Mediation Appraisal of Catastrophizing, Pain-Related Outcomes, and Race in Adults With Knee Osteoarthritis.J Pain. 2021 Nov;22(11):1452-1466. doi: 10.1016/j.jpain.2021.04.018. Epub 2021 May 24. J Pain. 2021. PMID: 34033964 Free PMC article.
-
Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes.Brain Behav Immun. 2018 May;70:141-156. doi: 10.1016/j.bbi.2018.02.009. Epub 2018 Feb 17. Brain Behav Immun. 2018. PMID: 29458194 Free PMC article.
-
Lesions of the central amygdala and ventromedial medulla reduce bladder hypersensitivity produced by acute but not chronic foot shock.Brain Res. 2017 Nov 15;1675:1-7. doi: 10.1016/j.brainres.2017.08.032. Epub 2017 Sep 1. Brain Res. 2017. PMID: 28867481 Free PMC article.
-
Different patterns of morphological changes in the hippocampus and dentate gyrus accompany the differential expression of disability following nerve injury.J Anat. 2014 Dec;225(6):591-603. doi: 10.1111/joa.12238. Epub 2014 Oct 1. J Anat. 2014. PMID: 25269883 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical