doi: 10.1002/art.1780200710.
The effect of synovial tissue on the breakdown of articular cartilage in organ culture
- PMID: 911354
- DOI: 10.1002/art.1780200710
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The effect of synovial tissue on the breakdown of articular cartilage in organ culture
Arthritis Rheum.
1977 Sep-Oct.
Abstract
Living (pig) cartilage in contact with synovium lost both proteoglycan and collagen and sometimes became reduced to a mass of fibroblast-like chondrocytes without matrix; dead cartilage lost proteoglycan but less collagen. Similar changes appeared in living cartilage grown at a distance from the synovium but in the same dish; dead cartilage was unaffected.
Conclusion: the synovium has a) a direct, presumably enzymatic action on cartilage matrix and b) an indirect effect mediated through the chondrocytes.
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