Safety and efficacy of nandrolone decanoate for treatment of wasting in patients with HIV infection
- PMID: 8805865
- DOI: 10.1097/00002030-199606001-00008
Safety and efficacy of nandrolone decanoate for treatment of wasting in patients with HIV infection
Abstract
Objective: To evaluate the safety and efficacy of the anabolic steroid, nandrolone decanoate (Deca Durabolin) in patients with HIV wasting who are resistant to nutritional intervention.
Design: A 16-week open trial with subjects who had lost 5-15% of their usual body weight.
Setting: HIV/AIDS specialist ambulatory care services, both public and private, in sydney, Australia.
Participants: Two hundred and twenty men entered the pre-therapy phase, and of these, 24 failed to gain weight and were enrolled. Seventeen subjects (81%) completed the 16-week trial.
Interventions: Pre-therapy nutritional assessment and education was conducted by the clinical dietitian. Those who failed to gain weight (10.9%) were treated with nandrolone decanoate (100 mg/ml) by deep intramuscular injection every 2 weeks for 16 weeks.
Main outcome measures: Changes in weight and body composition (lean body mass, total body water and nitrogen index) were measured by anthropometry, bioelectrical impedance, and in vivo neutron activation. Changes in quality of life were assessed by the 30-item Medical Outcomes Study short form questionnaire. Changes in biochemistry, haematology and immunology were also measured.
Results: There were significant increases in weight (mean, 0.14 kg per week; P < 0.05) and lean body mass (mean, 3 kg by anthropometry; P < 0.005). The change in lean body mass was of similar magnitude across all measurement modalities. Quality of life parameters, especially functionality, increased significantly during the trial. No subject experienced toxicity.
Conclusion: Nandrolone decanoate has beneficial effects on weight, lean body mass and quality of life in selected patients who have mild to moderate HIV wasting.
Similar articles
-
Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial.Arch Intern Med. 2005 Mar 14;165(5):578-85. doi: 10.1001/archinte.165.5.578. Arch Intern Med. 2005. PMID: 15767536 Clinical Trial.
-
Effects of nandrolone decanoate therapy in borderline hypogonadal men with HIV-associated weight loss.J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 1;20(2):137-46. doi: 10.1097/00042560-199902010-00005. J Acquir Immune Defic Syndr Hum Retrovirol. 1999. PMID: 10048900 Clinical Trial.
-
Treatment with nandrolone decanoate and megestrol acetate in HIV-infected men.Nutr Clin Pract. 2005 Feb;20(1):93-7. doi: 10.1177/011542650502000193. Nutr Clin Pract. 2005. PMID: 16207650
-
Clinical trials update in human immunodeficiency virus wasting.Semin Oncol. 1998 Apr;25(2 Suppl 6):104-11. Semin Oncol. 1998. PMID: 9625392 Review.
-
Anabolic steroids in COPD: a review and preliminary results of a randomized trial.Chron Respir Dis. 2008;5(3):169-76. doi: 10.1177/1479972308092350. Chron Respir Dis. 2008. PMID: 18684793 Review.
Cited by
-
Anabolic androgenic steroids and cardiomyopathy: an update.Front Cardiovasc Med. 2023 Jul 26;10:1214374. doi: 10.3389/fcvm.2023.1214374. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37564909 Free PMC article. Review.
-
Nandrolone decanoate administration does not attenuate muscle atrophy during a short period of disuse.PLoS One. 2019 Jan 28;14(1):e0210823. doi: 10.1371/journal.pone.0210823. eCollection 2019. PLoS One. 2019. PMID: 30689637 Free PMC article.
-
Effects of nandrolone decanoate on expression of steroidogenic enzymes in the rat testis.Asian-Australas J Anim Sci. 2018 May;31(5):658-671. doi: 10.5713/ajas.17.0899. Epub 2018 Mar 2. Asian-Australas J Anim Sci. 2018. PMID: 29514442 Free PMC article.
-
Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation.PLoS One. 2015 Jun 11;10(6):e0129686. doi: 10.1371/journal.pone.0129686. eCollection 2015. PLoS One. 2015. PMID: 26066046 Free PMC article.
-
Hypogonadism in human immunodeficiency virus-positive men.Korean J Urol. 2014 Jan;55(1):9-16. doi: 10.4111/kju.2014.55.1.9. Epub 2014 Jan 15. Korean J Urol. 2014. PMID: 24466391 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical