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Review
. 1996 Apr;36(4):341-55.
doi: 10.1080/10408399609527729.

Oxidatively modified LDL and atherosclerosis: an evolving plausible scenario

I Jialal  1 , C J Fuller
Affiliations
Review

Oxidatively modified LDL and atherosclerosis: an evolving plausible scenario

I Jialal et al. Crit Rev Food Sci Nutr. 1996 Apr.

Abstract

Much evidence has accumulated that implicates the oxidative modification of low-density lipoprotein (LDL) in the early stages of atherogenesis. The antioxidant nutrients alpha-tocopherol, ascorbic acid, and betacarotene have been shown to inhibit in vitro LDL oxidation. In addition, they have been shown to increase the resistance of LDL to oxidation when given to animals and humans. Because plasma levels of these nutrients can be increased by dietary supplementation with minimal side effects, they may show promise in the prevention of coronary artery disease.

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