Müllerian-inhibiting substance function during mammalian sexual development
- PMID: 7954809
- DOI: 10.1016/0092-8674(94)90251-8
Müllerian-inhibiting substance function during mammalian sexual development
Abstract
To investigate the role of Müllerian-inhibiting substance (MIS) in mammalian sexual development, we generated MIS-deficient mice. Although MIS-deficient males had testes that were fully descended and produced functional sperm, they also developed female reproductive organs, which interfered with sperm transfer into females, rendering most of these males infertile. Their testes had Leydig cell hyperplasia and, in one instance, neoplasia. The actions of the two primary hormones of male sexual differentiation were genetically eliminated using the testicular feminization (Tfm) mutation in combination with the MIS mutant allele. XY Tfm/MIS double mutants developed as females, with a uterus, coiled oviducts, and no male reproductive organs except undescended dysfunctional testes. These results suggest that eliminating the presumptive female reproductive tract in male fetuses facilitates fertility and that in testes MIS is a negative regulator of Leydig cell proliferation. Eliminating the presumptive male reproductive tract is necessary for proper oviductal morphogenesis during female mouse development.
Similar articles
-
Genetic studies of MIS signalling in sexual development.Novartis Found Symp. 2002;244:157-64; discussion 164-8, 203-6, 253-7. Novartis Found Symp. 2002. PMID: 11990789 Review.
-
New insights into mullerian inhibiting substance and its mechanism of action.J Endocrinol. 1998 Jul;158(1):1-6. doi: 10.1677/joe.0.1580001. J Endocrinol. 1998. PMID: 9713320 Review.
-
The müllerian inhibitor and mammalian sexual development.Philos Trans R Soc Lond B Biol Sci. 1995 Nov 29;350(1333):285-8; discussion 289. doi: 10.1098/rstb.1995.0163. Philos Trans R Soc Lond B Biol Sci. 1995. PMID: 8570693
-
The in vivo roles of müllerian-inhibiting substance.Curr Top Dev Biol. 1994;29:171-87. doi: 10.1016/s0070-2153(08)60550-5. Curr Top Dev Biol. 1994. PMID: 7828438 Review.
-
Abnormal sexual development in transgenic mice chronically expressing müllerian inhibiting substance.Nature. 1990 May 10;345(6271):167-70. doi: 10.1038/345167a0. Nature. 1990. PMID: 2336108
Cited by
-
Conserved genes regulating human sex differentiation, gametogenesis and fertilization.J Transl Med. 2024 May 19;22(1):473. doi: 10.1186/s12967-024-05162-2. J Transl Med. 2024. PMID: 38764035 Free PMC article. Review.
-
Anti-Müllerian hormone, testicular descent and cryptorchidism.Front Endocrinol (Lausanne). 2024 Mar 4;15:1361032. doi: 10.3389/fendo.2024.1361032. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38501100 Free PMC article. Review.
-
Mini review: Asymmetric Müllerian duct development in the chicken embryo.Front Cell Dev Biol. 2024 Feb 5;12:1347711. doi: 10.3389/fcell.2024.1347711. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38380340 Free PMC article. Review.
-
Extraordinary variability in gene activation and repression programs during gonadal sex differentiation across vertebrates.Front Cell Dev Biol. 2024 Jan 23;12:1328365. doi: 10.3389/fcell.2024.1328365. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38322165 Free PMC article.
-
Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface.Am J Reprod Immunol. 2023 Dec;90(6):e13789. doi: 10.1111/aji.13789. Am J Reprod Immunol. 2023. PMID: 38009061 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases