A placental clock controlling the length of human pregnancy
- PMID: 7585095
- DOI: 10.1038/nm0595-460
A placental clock controlling the length of human pregnancy
Abstract
We report the existence of a 'placental clock', which is active from an early stage in human pregnancy and determines the length of gestation and the timing of parturition and delivery. Using a prospective, longitudinal cohort study of 485 pregnant women we have demonstrated that placental secretion of corticotropin-releasing hormone (CRH) is a marker of this process and that measurement of the maternal plasma CRH concentration as early as 16-20 weeks of gestation identifies groups of women who are destined to experience normal term, preterm or post-term delivery. Further, we report that the exponential rise in maternal plasma CRH concentrations with advancing pregnancy is associated with a concomitant fall in concentrations of the specific CRH binding protein in late pregnancy, leading to a rapid increase in circulating levels of bioavailable CRH at a time that coincides with the onset of parturition, suggesting that CRH may act directly as a trigger for parturition in humans.
Comment in
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CRH, a placental clock and preterm labour.Nat Med. 1995 May;1(5):416. doi: 10.1038/nm0595-416. Nat Med. 1995. PMID: 7585086 No abstract available.
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