Folate status throughout pregnancy and in postpartum period
- PMID: 5683581
- PMCID: PMC1912617
- DOI: 10.1136/bmj.4.5627.356
Folate status throughout pregnancy and in postpartum period
Abstract
The serial trends of the whole blood folate level in two groups of patients have been followed throughout pregnancy and up to six weeks postpartum. In those receiving iron alone the whole blood folate remained normal until the test at six weeks after delivery, at which time over half were in the deficient range. There appears to be a delay before this test reflects the current folate status when this changes rapidly. In those receiving iron plus 330 mug. of folic acid a day the results at this time were close to those at the beginning of pregnancy. Subnormal whole blood folate, red cell folate, and serum folate values occurred close to term in patients receiving iron alone, but were not found in those also receiving folic acid. Megaloblastic changes occurred at term in three patients receiving iron alone in whom the whole blood folate had repeatedly been low in early pregnancy.The observations are consistent with the previous suggestion that 300 mug. of folic acid daily is a suitable supplement to prevent deficiency in late pregnancy and the puerperium.
Similar articles
-
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.Am J Obstet Gynecol. 1971 Feb 1;109(3):341-6. doi: 10.1016/0002-9378(71)90326-7. Am J Obstet Gynecol. 1971. PMID: 5549181
-
A prophylactic trial of iron and folic acid supplements in pregnant Burmese women.Isr J Med Sci. 1976 Dec;12(12):1410-7. Isr J Med Sci. 1976. PMID: 138664 Clinical Trial.
-
Iron, zinc and folate status during pregnancy and two months after delivery.Acta Obstet Gynecol Scand. 1986;65(1):15-22. doi: 10.3109/00016348609158223. Acta Obstet Gynecol Scand. 1986. PMID: 3716775
-
The role of folic acid in deficiency states and prevention of disease.J Fam Pract. 1997 Feb;44(2):138-44. J Fam Pract. 1997. PMID: 9040515 Review.
-
Folic acid with or without vitamin B12 for cognition and dementia.Cochrane Database Syst Rev. 2003;(4):CD004514. doi: 10.1002/14651858.CD004514. Cochrane Database Syst Rev. 2003. Update in: Cochrane Database Syst Rev. 2008 Oct 08;(4):CD004514. doi: 10.1002/14651858.CD004514.pub2. PMID: 14584018 Updated. Review.
Cited by
-
The Importance of Maternal Folate Status for Brain Development and Function of Offspring.Adv Nutr. 2019 May 1;10(3):502-519. doi: 10.1093/advances/nmy120. Adv Nutr. 2019. PMID: 31093652 Free PMC article. Review.
-
Intermittent oral iron supplementation during pregnancy.Cochrane Database Syst Rev. 2015 Oct 19;2015(10):CD009997. doi: 10.1002/14651858.CD009997.pub2. Cochrane Database Syst Rev. 2015. PMID: 26482110 Free PMC article. Review.
-
Daily oral iron supplementation during pregnancy.Cochrane Database Syst Rev. 2015 Jul 22;2015(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. Cochrane Database Syst Rev. 2015. PMID: 26198451 Free PMC article. Review.
-
Nutrient intake values for folate during pregnancy and lactation vary widely around the world.Nutrients. 2013 Sep 30;5(10):3920-47. doi: 10.3390/nu5103920. Nutrients. 2013. PMID: 24084052 Free PMC article. Review.
-
Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes.Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD006896. doi: 10.1002/14651858.CD006896.pub2. Cochrane Database Syst Rev. 2013. PMID: 23543547 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical