Maternal-fetal transfer of ascorbic acid in the guinea pig
- PMID: 512708
- DOI: 10.1093/jn/109.12.2205
Maternal-fetal transfer of ascorbic acid in the guinea pig
Abstract
Placental transfer of ascorbic acid was studied in the guinea pig using an in situ placental perfusion technique. A total of 14 animals were studied during their last week of gestation. The fetus was shown to have higher plasma total ascorbic acid (TAA) levels than the mother prior to maternal ascorbic acid infusion. However, following maternal venous infusion this normal gradient for TAA (fetal greater than maternal) disappeared and a new gradient was established (maternal greater than fetal). As maternal plasma TAA levels rose, the level of TAA in the placental perfusate steadily increased to a maximal concentration of approximately 0.85 mg/dl. This occurred when maternal plasma TAA levels were above 3.0 mg/dl. These results demonstrate that a saturable or carrier-mediated transport mechanism is involved in the placental transfer of ascorbic acid in this species. The apparent Vmax (the maximal transport rate by the saturable system per gram placenta) and the Kt (or one-half saturation concentration) were estimated to be 8.3 nmoles/minute and 0.12 mM, respectively. Additional results are presented to suggest that dehydroascorbic acid (DHA) may be the predominant form of the vitamin crossing the guinea pig placenta.
Similar articles
-
Placental transfer of free fatty acids: factors affecting transfer across the guinea-pig placenta.J Dev Physiol. 1983 Oct;5(5):323-32. J Dev Physiol. 1983. PMID: 6643955
-
A comparative study of ascorbic acid entry into aqueous and vitreous humors of the rat and guinea pig.Invest Ophthalmol Vis Sci. 1989 Nov;30(11):2320-31. Invest Ophthalmol Vis Sci. 1989. PMID: 2807790
-
Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs.Br J Nutr. 2013 Nov 14;110(9):1573-9. doi: 10.1017/S0007114513000913. Epub 2013 Apr 16. Br J Nutr. 2013. PMID: 23591139
-
Placental transfer of non-esterified fatty acids in normal and diabetic pregnancy.Biol Neonate. 1987;51(2):94-101. doi: 10.1159/000242638. Biol Neonate. 1987. PMID: 3552063 Review.
-
Control of placental glucose transfer.Placenta. 1987 Nov-Dec;8(6):557-71. doi: 10.1016/0143-4004(87)90027-0. Placenta. 1987. PMID: 3325968 Review.
Cited by
-
Ascorbic Acid and the Premature Infant.Nutrients. 2022 May 24;14(11):2189. doi: 10.3390/nu14112189. Nutrients. 2022. PMID: 35683989 Free PMC article.
-
Maternal Supplementation with Antioxidant Vitamins in Sheep Results in Increased Transfer to the Fetus and Improvement of Fetal Antioxidant Status and Development.Antioxidants (Basel). 2019 Mar 8;8(3):59. doi: 10.3390/antiox8030059. Antioxidants (Basel). 2019. PMID: 30857206 Free PMC article.
-
Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs.Eur J Nutr. 2015 Jun;54(4):667-76. doi: 10.1007/s00394-014-0809-6. Epub 2014 Dec 4. Eur J Nutr. 2015. PMID: 25472559
-
Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs.PLoS One. 2012;7(10):e48488. doi: 10.1371/journal.pone.0048488. Epub 2012 Oct 31. PLoS One. 2012. PMID: 23119033 Free PMC article.
-
The effect of maternal and cord-blood vitamin C, vitamin E and lipid peroxide levels on newborn birth weight.Mol Cell Biochem. 2008 Feb;309(1-2):217-21. doi: 10.1007/s11010-007-9638-8. Epub 2007 Nov 30. Mol Cell Biochem. 2008. PMID: 18049868
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials