doi: 10.1093/ajcn/32.3.530.
Steady-state turnover and body pool of ascorbic acid in man
- PMID: 420145
- DOI: 10.1093/ajcn/32.3.530
Item in Clipboard
Steady-state turnover and body pool of ascorbic acid in man
Am J Clin Nutr.
1979 Mar.
Abstract
The time course of radioactivity in plasma and urine after oral administration of a single dose of (1-14C)ascorbic acid has been followed in healthy nonsmoking male volunteers. The investigation was carried out under steady state conditions with regard to ascorbic acid intake (30 to 180 mg/day). Using pharmacokinetic principles, turnover, pool size, and rates of metabolism and excretion could be calculated. It was found that the half-life of ascorbic acid was inversely related to the dosage and that the pool could be increased to about 20 mg/kg bodyweight by increasing the dosage. It was concluded that on a daily intake of about 100 mg ascorbic acid this pool size would be reached in 95% of the population.
Similar articles
-
On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers.Am J Clin Nutr. 1981 Jul;34(7):1347-55. doi: 10.1093/ajcn/34.7.1347. Am J Clin Nutr. 1981. PMID: 7258125
-
Metabolism and requirements of ascorbic acid in man.S Afr Med J. 1981 Nov 21;60(21):818-23. S Afr Med J. 1981. PMID: 7029735 Review.
-
Absorption of large, single, oral intakes of ascorbic acid.Int J Vitam Nutr Res. 1980;50(3):309-14. Int J Vitam Nutr Res. 1980. PMID: 7429760
-
Effect of oral administration of large quantities of ascorbic acid on blood levels and urinary excretion of ascorbic acid in healthy men.Int J Vitam Nutr Res. 1975;45(2):237-43. Int J Vitam Nutr Res. 1975. PMID: 1165168
-
Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review.Arzneimittelforschung. 2001 Sep;51(9):699-725. doi: 10.1055/s-0031-1300105. Arzneimittelforschung. 2001. PMID: 11642003 Review.
Cited by
-
Vitamin C - a scoping review for Nordic Nutrition Recommendations 2023.Food Nutr Res. 2023 Dec 28;67. doi: 10.29219/fnr.v67.10300. eCollection 2023. Food Nutr Res. 2023. PMID: 38187788 Free PMC article. Review.
-
Dietary Sources, Bioavailability, and Functions of Ascorbic Acid (Vitamin C) and Its Role in the Common Cold, Tissue Healing, and Iron Metabolism.Cureus. 2023 Nov 23;15(11):e49308. doi: 10.7759/cureus.49308. eCollection 2023 Nov. Cureus. 2023. PMID: 38146585 Free PMC article. Review.
-
Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak.Am J Clin Nutr. 2022 Jul 6;116(1):274-284. doi: 10.1093/ajcn/nqac063. Am J Clin Nutr. 2022. PMID: 35537862 Free PMC article.
-
Lost-in-Translation of Metabolic Effects of Inorganic Nitrate in Type 2 Diabetes: Is Ascorbic Acid the Answer?Int J Mol Sci. 2021 Apr 29;22(9):4735. doi: 10.3390/ijms22094735. Int J Mol Sci. 2021. PMID: 33947005 Free PMC article. Review.
-
High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients.Cancers (Basel). 2021 Mar 20;13(6):1428. doi: 10.3390/cancers13061428. Cancers (Basel). 2021. PMID: 33804775 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources