Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 27:S0896-6273(24)00414-8.
doi: 10.1016/j.neuron.2024.06.007. Online ahead of print.

Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development

David C Wang  1 , Fernando Santos-Valencia  2 , Jun H Song  3 , Kevin M Franks  4 , Liqun Luo  5
Affiliations
Free article

Embryonically active piriform cortex neurons promote intracortical recurrent connectivity during development

David C Wang et al. Neuron. .
Free article

Abstract

Neuronal activity plays a critical role in the maturation of circuits that propagate sensory information into the brain. How widely does early activity regulate circuit maturation across the developing brain? Here, we used targeted recombination in active populations (TRAP) to perform a brain-wide survey for prenatally active neurons in mice and identified the piriform cortex as an abundantly TRAPed region. Whole-cell recordings in neonatal slices revealed preferential interconnectivity within embryonically TRAPed piriform neurons and their enhanced synaptic connectivity with other piriform neurons. In vivo Neuropixels recordings in neonates demonstrated that embryonically TRAPed piriform neurons exhibit broad functional connectivity within piriform and lead spontaneous synchronized population activity during a transient neonatal period, when recurrent connectivity is strengthening. Selectively activating or silencing these neurons in neonates enhanced or suppressed recurrent synaptic strength, respectively. Thus, embryonically TRAPed piriform neurons represent an interconnected hub-like population whose activity promotes recurrent connectivity in early development.

Keywords: Fos; Neuropixels recording; TRAP2; activity-dependent wiring; embryonic activity; hub-like population; piriform cortex; recurrent network; synchronized population activity; whole-cell recording.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests L.L. is a member of Neuron’s advisory board.

Update of

Similar articles

See all similar articles

LinkOut - more resources