The single-cell opioid responses in the context of HIV (SCORCH) consortium

Seth A Ament¹, Rianne R Campbell², Mary Kay Lobo², Joseph P Receveur², Kriti Agrawal³, Alejandra Borjabad⁴, Siddappa N Byrareddy⁵, Linda Chang², Declan Clarke³, Prashant Emani³, Dana Gabuzda⁶, Kyle J Gaulton⁷, Michelle Giglio², Federico M Giorgi⁸, Busra Gok⁹, Chittibabu Guda⁵, Eran Hadas⁴, Brian R Herb², Wen Hu¹⁰, Anita Huttner³, Mohammad R Ishmam⁴, Michelle M Jacobs⁴, Jennifer Kelschenbach⁴, Dong-Wook Kim¹¹, Cheyu Lee¹², Shuhui Liu⁴, Xiaokun Liu⁴, Bertha K Madras¹³, Anup A Mahurkar², Deborah C Mash¹⁴, Eran A Mukamel⁷, Meng Niu⁵, Richard M O'Connor⁴, Chelsea M Pagan¹¹, Alina P S Pang¹⁰, Piya Pillai⁴, Vez Repunte-Canonigo¹⁵, W Brad Ruzicka¹³, Jay Stanley³, Timothy Tickle¹⁶, Shang-Yi A Tsai¹⁷, Allen Wang⁷, Lauren Wills⁴, Alyssa M Wilson⁴, Susan N Wright¹⁷, Siwei Xu¹², Junchen Yang³, Maryam Zand⁷, Le Zhang³, Jing Zhang¹², Schahram Akbarian⁴, Shilpa Buch⁵, Christine S Cheng⁷, Michael J Corley¹⁰, Howard S Fox⁵, Mark Gerstein³, Suryaram Gummuluru⁹, Myriam Heiman¹⁸, Ya-Chi Ho³, Manolis Kellis¹⁸, Paul J Kenny⁴, Yuval Kluger³, Teresa A Milner¹⁰, David J Moore⁷, Susan Morgello⁴, Lishomwa C Ndhlovu¹⁰, Tariq M Rana⁷, Pietro Paolo Sanna¹⁵, John S Satterlee¹⁷, Nenad Sestan³, Stephen A Spector⁷, Serena Spudich³, Hagen U Tilgner¹⁰, David J Volsky⁴, Owen R White², Dionne W Williams¹⁹, Hongkui Zeng¹¹

Affiliations

¹ University of Maryland School of Medicine, Baltimore, MD, USA. sament@som.umaryland.edu.
² University of Maryland School of Medicine, Baltimore, MD, USA.
³ Yale School of Medicine, New Haven, CT, USA.
⁴ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁵ University of Nebraska Medical Center, Omaha, NE, USA.
⁶ Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
⁷ University of California San Diego, La Jolla, CA, USA.
⁸ University of Bologna, Bologna, Italy.
⁹ Boston University, Boston, MA, USA.
¹⁰ Weill Cornell Medicine, New York, NY, USA.
¹¹ Allen Institute for Brain Science, Seattle, WA, USA.
¹² University of California Irvine, Irvine, CA, USA.
¹³ McLean Hospital, Harvard Medical School, Belmont, MA, USA.
¹⁴ University of Miami, Miami, FL, USA.
¹⁵ The Scripps Research Institute, La Jolla, CA, USA.
¹⁶ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁷ National Institute on Drug Abuse, Bethesda, MD, USA.
¹⁸ Massachusetts Institute of Technology, Cambridge, MA, USA.
¹⁹ Emory University School of Medicine, Atlanta, GA, USA.

PMID: 38879719
DOI: 10.1038/s41380-024-02620-7

Review

The single-cell opioid responses in the context of HIV (SCORCH) consortium

Seth A Ament et al. Mol Psychiatry. 2024.

. 2024 Jun 15.

doi: 10.1038/s41380-024-02620-7. Online ahead of print.

Authors

Affiliations

¹ University of Maryland School of Medicine, Baltimore, MD, USA. sament@som.umaryland.edu.
² University of Maryland School of Medicine, Baltimore, MD, USA.
³ Yale School of Medicine, New Haven, CT, USA.
⁴ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁵ University of Nebraska Medical Center, Omaha, NE, USA.
⁶ Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
⁷ University of California San Diego, La Jolla, CA, USA.
⁸ University of Bologna, Bologna, Italy.
⁹ Boston University, Boston, MA, USA.
¹⁰ Weill Cornell Medicine, New York, NY, USA.
¹¹ Allen Institute for Brain Science, Seattle, WA, USA.
¹² University of California Irvine, Irvine, CA, USA.
¹³ McLean Hospital, Harvard Medical School, Belmont, MA, USA.
¹⁴ University of Miami, Miami, FL, USA.
¹⁵ The Scripps Research Institute, La Jolla, CA, USA.
¹⁶ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁷ National Institute on Drug Abuse, Bethesda, MD, USA.
¹⁸ Massachusetts Institute of Technology, Cambridge, MA, USA.
¹⁹ Emory University School of Medicine, Atlanta, GA, USA.

PMID: 38879719
DOI: 10.1038/s41380-024-02620-7

Abstract

Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of the seminal challenges in treating and studying addiction in human populations is the high prevalence of co-morbid conditions, including an increased risk of contracting a human immunodeficiency virus (HIV) infection. Of the ~15 million people who inject drugs globally, 17% are persons with HIV. Conversely, HIV is a risk factor for SUD because chronic pain syndromes, often encountered in persons with HIV, can lead to an increased use of opioid pain medications that in turn can increase the risk for opioid addiction. We hypothesize that SUD and HIV exert shared effects on brain cell types, including adaptations related to neuroplasticity, neurodegeneration, and neuroinflammation. Basic research is needed to refine our understanding of these affected cell types and adaptations. Studying the effects of SUD in the context of HIV at the single-cell level represents a compelling strategy to understand the reciprocal interactions among both conditions, made feasible by the availability of large, extensively-phenotyped human brain tissue collections that have been amassed by the Neuro-HIV research community. In addition, sophisticated animal models that have been developed for both conditions provide a means to precisely evaluate specific exposures and stages of disease. We propose that single-cell genomics is a uniquely powerful technology to characterize the effects of SUD and HIV in the brain, integrating data from human cohorts and animal models. We have formed the Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium to carry out this strategy.

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References

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The single-cell opioid responses in the context of HIV (SCORCH) consortium

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The single-cell opioid responses in the context of HIV (SCORCH) consortium

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