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. 2024 Jun 5.
doi: 10.1007/s12928-024-01020-6. Online ahead of print.

Adverse clinical events after percutaneous coronary intervention in very elderly patients with acute coronary syndrome

Takanori Kawamoto #  1 , Hisao Otsuki #  1 , Hiroyuki Arashi  2 , Kentaro Jujo  3   4   5 , Toshiaki Oka  6 , Fumiaki Mori  7 , Hiroyuki Tanaka  8 , Tomohiro Sakamoto  9 , Yasuhiro Ishii  10 , Yutaka Terajima  11 , Masahiro Yagi  12 , Atsushi Takagi  13 , Shoji Haruta  14 , Junichi Yamaguchi  1
Affiliations

Adverse clinical events after percutaneous coronary intervention in very elderly patients with acute coronary syndrome

Takanori Kawamoto et al. Cardiovasc Interv Ther. .

Abstract

The number of very elderly patients with acute coronary syndrome (ACS) is increasing. Therefore, owing to the need for evidence-based treatment decisions in this population, this study aimed to examine the clinical outcomes during 1 year after percutaneous coronary intervention (PCI) in very elderly patients with ACS. This prospective multicenter observational study comprised 1337 patients with ACS treated with PCI, classified into the following four groups according to age: under 60, <60 years; sexagenarian, ≥60 and <69 years; septuagenarian, ≥70 and <80 years; and very elderly, ≥80 years. The primary endpoint was a composite of the first occurrence of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and bleeding within 1 year after PCI. We used the sexagenarian group as a reference and compared outcomes with those of the other groups. The incidence of the primary endpoint was significantly higher in the very elderly group than in the sexagenarian group (36 [12.7%] vs. 24 [6.9%], respectively; hazard ratio, 1.94; 95% confidence interval: 1.16-3.26; p = 0.012). The higher incidence of the primary endpoint was primarily driven by a higher incidence of all-cause death. When the multivariable analysis was used to adjust for patient characteristics and comorbidities, no difference was observed in the primary endpoint between the very elderly and sexagenarian groups (p = 0.96). The incidence of adverse events after PCI, particularly all-cause death, in very elderly patients with ACS was high. However, if several confounders are adjusted, comparable outcomes may be expected within 1 year after PCI among this population.

Keywords: Acute coronary syndrome; All-cause death; Elderly patients; Percutaneous coronary intervention.

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