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Review
. 2024 May 3;14(5):488.
doi: 10.3390/jpm14050488.

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Anton Shkundin  1 , Angelos Halaris  1
Affiliations
Review

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Anton Shkundin et al. J Pers Med. .

Abstract

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation and disease progression. Additionally, CXCL8 gene polymorphisms can alter IL-8 production, leading to potential differences in disease susceptibility, progression, and severity across populations. IL-8 levels vary among neuropsychiatric conditions, demonstrating sensitivity to psychosocial stressors and disease severity. IL-8 can be detected in blood circulation, cerebrospinal fluid (CSF), and urine, making it a promising candidate for a broad-spectrum biomarker. This review highlights the need for further research on the diverse effects of IL-8 and the associated implications for personalized medicine. A thorough understanding of its complex role could lead to the development of more effective and personalized treatment strategies for neuropsychiatric conditions.

Keywords: CXCL8; CXCR1; CXCR2; IL-8; SNPs.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic presentation of IL-8 inducers: IL-1α, IL-1β, IL-7, IL-17, IL-22, tumor necrosis factor-alpha (TNF-α), histamine, stromal cell-derived factor-1 (SDF-1, CXCL12), lipopolysaccharides (LPSs), reactive oxygen species (ROS), cadmium (Cd), phytohemagglutinin (PHA), prostaglandin E2, polyinosinic-polycytidylic acid (poly I:C), concanavalin A (ConA), NaCl, thrombin, and all-trans-retinoic acid (ATRA).
Figure 2
Figure 2
Schematic presentation of IL-8 reducers: IL-4, IL-10, IL-35, transforming growth factor-beta 1 (TGF-β1), interferon-alpha (IFN-α), interferon-beta (IFN-β), glucocorticoids (GCs), lipoxins, vitamin D, lipoxygenase (LOX) inhibitors, antcin K, tannins, glycyrrhizin (GL), and N-acetylcysteine (NAC).
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