Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr 25;60(5):707.
doi: 10.3390/medicina60050707.

Recent Trends in Adipose Tissue-Derived Injectable Therapies for Osteoarthritis: A Scoping Review of Animal Models

Alina Otilia Adam  1 , Horea Rares Ciprian Benea  1 , Horia Mihnea Fotescu  2 , Miriam Alcalá Ruiz  1 , George Claudiu Cimpean  1 , Vladimir Ciornei  1 , Arsenii Cernacovschi  1 , Andrei Rares Edves  1 , Maria Crisan  3
Affiliations
Review

Recent Trends in Adipose Tissue-Derived Injectable Therapies for Osteoarthritis: A Scoping Review of Animal Models

Alina Otilia Adam et al. Medicina (Kaunas). .

Abstract

Background and Objectives: This scoping review investigates recent trends in adipose tissue-derived injectable therapies for osteoarthritis (OA) in animal models, focusing on minimally manipulated or lightly processed adipose tissue. By evaluating and examining the specific context in which these therapies were investigated across diverse animal OA models, this review aims to provide valuable insights that will inform and guide future research and clinical applications in the ongoing pursuit of effective treatments for osteoarthritis. Materials and Methods: This research conducted a comprehensive literature review of PubMed and Embase to determine studies about minimally manipulated adipose tissue-derived injectable therapies for osteoarthritis investigated using animal models. The primary search found 530 results. After excluding articles that focused on spontaneous osteoarthritis; on transfected, preconditioned, cultured, or co-cultured adipose-derived stem cells; and articles with unavailable full text, we included 11 articles in our review. Results: The examined therapies encompassed mechanical micro-fragmented adipose tissue (MFAT) and stromal vascular fraction (SVF) obtained via collagenase digestion and centrifugation. These interventions were evaluated across various animal models, including mice, rats, rabbits, and sheep with induced OA. Notably, more studies concentrated on surgically induced OA rather than chemically induced OA. The assessment of these therapies focused on elucidating their protective immunomodulatory, anti-inflammatory, and chondroregenerative potential through comprehensive evaluations, including macroscopic assessments, histological analyses, immunohistochemical examinations, and biochemical assays. Conclusions: This review provides a comprehensive analysis of adipose tissue-derived injectable therapies for osteoarthritis across diverse animal models. While revealing potential benefits and insights, the heterogeneity of data and the limited number of studies highlight the need for further research to formulate conclusive recommendations for clinical applications.

Keywords: adipose tissue-derived injectable therapies; animal model; fragmented adipose tissue; osteoarthritis; stromal vascular fraction.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
SYRCLE’s risk of bias tool assessment of the included studies. The bar chart illustrates the proportion of studies meeting each quality criteria.
Figure 2
Figure 2
Prisma flow diagram.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Samvelyan H.J., Hughes D., Stevens C., Staines K.A. Models of Osteoarthritis: Relevance and New Insights. Calcif. Tissue Int. 2021;109:243–256. doi: 10.1007/s00223-020-00670-x. - DOI - PMC - PubMed
    1. Leifer V.P., Katz J.N., Losina E. The burden of OA-health services and economics. Osteoarthr. Cartil. 2022;30:10–16. doi: 10.1016/j.joca.2021.05.007. - DOI - PMC - PubMed
    1. Wojdasiewicz P., Poniatowski Ł.A., Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediat. Inflamm. 2014;2014:561459. doi: 10.1155/2014/561459. - DOI - PMC - PubMed
    1. Fujii Y., Liu L., Yagasaki L., Inotsume M., Chiba T., Asahara H. Cartilage Homeostasis and Osteoarthritis. Int. J. Mol. Sci. 2022;23:6316. doi: 10.3390/ijms23116316. - DOI - PMC - PubMed
    1. Chow Y.Y., Chin K.Y. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediat. Inflamm. 2020;2020:8293921. doi: 10.1155/2020/8293921. - DOI - PMC - PubMed

Grants and funding

This research received no external funding.