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Review
. 2024 Apr 23;13(2):139-147.
doi: 10.7762/cnr.2024.13.2.139. eCollection 2024 Apr.

The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials

Sogand Saadatmand  1 , Foad Zohroudi  1 , Hadith Tangestani  2
Affiliations
Review

The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials

Sogand Saadatmand et al. Clin Nutr Res. .

Abstract

Anxiety disorder is a prevalent psychiatric issue that affects 4.05% of the global population. As complementary and alternative medicine gains popularity, many individuals with anxiety symptoms seek herbal remedies. This systematic review aims to explore the sedative efficacy of chamomile as an herbal medicine for anxiety treatment. Our search was conducted in PubMed, Google Scholar, and Scopus databases until August 2023. Among 389 papers found, after removing duplicates and irrelevant papers, 10 clinical trials investigating the effect of oral consumption of chamomile on anxiety were included. Two researchers independently completed all steps, including the screening process and data extraction. Out of the 10 articles selected, 9 studies have concluded that chamomile is effective in reducing anxiety. Even though, the exact mechanism of chamomile's anxiolytic action is not well understood, evidence suggests that its active compounds, including apigenin, may modulate the function of the hypothalamic-pituitary-adrenocortical axis by affecting neurotransmitter pathways. This systematic review showed that chamomile potentially has an anxiolytic effect. In addition, due to the side effects of drugs used to treat anxiety disorders, the use of chamomile seems to be effective and less dangerous.

Keywords: Anxiety; Anxiety disorder; Chamomile; Systematic review.

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Conflict of interest statement

Conflict of Interest: The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. The process of study selection.
Three hundred eighty-nine articles were found in databases. After removing duplicate articles (n = 55), 324 articles were excluded by 2 steps of screening. Finally, 10 articles were included in the systematic review.
See this image and copyright information in PMC

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