Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 15.
doi: 10.1038/s41372-024-01979-3. Online ahead of print.

Presurgical pulmonary function tests in the first few days of life in neonates with congenital heart disease, a pilot study

Hayden Leeds  1 , Ashok Muralidaran  2 , Alicia J Johnson  3 , Diane Schilling  4 , Kseniya Parkhotyuk  4 , Irving Shen  2 , Cindy T McEvoy  4
Affiliations

Presurgical pulmonary function tests in the first few days of life in neonates with congenital heart disease, a pilot study

Hayden Leeds et al. J Perinatol. .

Abstract

Objective: To compare early pulmonary function tests (PFTs) in neonates with critical congenital heart disease (CHD) compared to a historical reference group.

Design: Infants ≥ 37 weeks gestation with critical CHD were studied within the first few days of life, prior to cardiac surgery, and compared to data from a published reference group of healthy term neonates without CHD, studied at the same institution. Passive respiratory resistance (Rrs) and compliance (Crs) were measured with the single breath occlusion technique following specific acceptance criteria. The study was powered for a 30% difference in Rrs.

Results: PFTs in 24 infants with CHD were compared to 31 historical reference infants. There was no difference in the Rrs between the groups. The infants with CHD had a significantly decreased Crs (1.02 ± 0.26 mL/cmH2O/kg versus 1.32 ± 0.36; (p < 0.05; mean ± SD)).

Conclusions: Further prospective studies are required to quantify early PFTs in infants with CHD of different phenotypes.

PubMed Disclaimer

Update of

Similar articles

See all similar articles

References

    1. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39:1890–900. - DOI - PubMed
    1. Friedman AHF JT. The transition from fetal to neonatal circulation: normal responses and implications for infants wtih heart disease. Semin Perinatol. 1993;17:106–21.
    1. Hauck A, Porta N, Lestrud S, Berger S. The pulmonary circulation in the single ventricle patient. Children. 2017;4:71.
    1. Simonato M, Padalino M, Vedovelli L, Carollo C, Sartori A, Vida V, et al. Effect of preoperative pulmonary hemodynamic and cardiopulmonary bypass on lung function in children with congenital heart disease. Eur J Pediatr. 2023;182:2549–57. - DOI - PubMed - PMC
    1. Stayer SA, Diaz LK, East DL, Gouvion JN, Vencill TL, McKenzie ED, et al. Changes in respiratory mechanics among infants undergoing heart surgery. Anesth Analg. 2004;98:49–55. - DOI - PubMed

LinkOut - more resources