Verteporfin suppressed mitophagy via PINK1/parkin pathway in endometrial cancer
- PMID: 38726279
- PMCID: PMC11076261
- DOI: 10.62347/PMYV3832
Verteporfin suppressed mitophagy via PINK1/parkin pathway in endometrial cancer
Abstract
Endometrial cancer (EC) is a malignancy that poses a threat to woman's health worldwide. Building upon prior work, we explored the inhibitory effect of verteporfin on EC. We showed that verteporfin can damage the mitochondria of EC cells, leading to a decrease of mitochondrial membrane potential and an increase in ROS (reactive oxygen species). In addition, verteporfin treatment was shown to inhibit the proliferation and migration of EC cells, promote apoptosis, and reduce the expression of mitophagy-related proteins PINK1/parkin and TOM20. The ROS inhibitor N-Acetyl Cysteine was able to rescue the expression of PINK1/parkin proteins. This suggests that verteporfin may inhibit mitophagy by elevating ROS levels, thereby inhibiting EC cell viability. The effect of verteporfin on mitophagy supports further investigation as a potential therapeutic option for EC.
Keywords: Endometrial cancer; PINK1/parkin pathway; mitophagy; verteporfin.
AJCR Copyright © 2024.
Conflict of interest statement
None.
Figures
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