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Review
. 2024 Apr 25;10(9):e29707.
doi: 10.1016/j.heliyon.2024.e29707. eCollection 2024 May 15.

A comprehensive account on ethnobotany, phytochemistry and pharmacological insights of genus Celtis

Md Abdus Samadd  1   2 , Md Jamal Hossain  2 , Miss Sharmin Zahan  2 , Md Monirul Islam  2 , Mohammad A Rashid  1
Affiliations
Review

A comprehensive account on ethnobotany, phytochemistry and pharmacological insights of genus Celtis

Md Abdus Samadd et al. Heliyon. .

Abstract

The plants of Celtis L. genus have been traditionally used to cure aches, sore throats, fevers, cancer, sexually transmitted diseases, sexual weakness, diarrhea, stomach problems, amenorrhea, menstrual disorders, kidney stones, and pain. The review aims to give a comprehensive account of the current state of ethnopharmacology, phytochemistry, and biological activities of the Celtis genus, as well as to describe the potential area of future avenues. Information on the Celtis genus was obtained from internet sources such as Google Scholar, Web of Science, PubMed, ScienceDirect, and so on by using appropriate keywords, including ethnobotanical, pharmacological, pharmaceutical, bioactivity, phytochemistry, and botanical features of the Celtis genus. This review identified 14 species in the genus Celtis that have a phytopharmacological investigation, including C.africana Burm. f., C. australis L., C. occidentalis L., C. sinensis Pers., C. philippensis Blanco., C. tetrandra Roxb., C. tessmannii Rendle., C. jessoensis Koidz., C. adolfi-friderici Engl., C. iguanaea (Jacq.) Sarg., C. laevigata Wild., C. pallida Torr., C. zenkeri Engl., and C. tournefortii Lam. This genus contains many classified phytoconstituents, such as terpenoids, organic acids, flavonoids, and volatile compounds. Their extracts and pure substances have been shown to have the same anticancer, antibacterial, anti-inflammatory, antioxidant, hepatoprotective, cardioprotective, urease-inhibiting, and antidiarrheal properties as their traditional uses. In terms of current information on ethnopharmacology, phytochemicals, and pharmacological uses, the data acquired in this review could be beneficial and needed for future research. Some phytoconstituents (for instance, kaempferol, myricetin, quercetin, and eugenol) and extracts (for example, leaves, seeds, and ripe fruits extracts of C. australis) showed tremendous results in preliminary testing with promising antimicrobial, anticancer, and urease inhibitory effects. Further research and clinical investigations are needed to develop them as lead compounds and neutraceuticals, which may provide an advance over traditional medicinal systems.

Keywords: Biological activities; Cannabaceae; Celtis; Ethnopharmacology; Phytochemistry.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
The article selection procedure following the preferred reporting items for systematic review and meta-analysis (PRISMA) protocols.
Fig. 2
Fig. 2
Amides from the genus Celtis.
Fig. 3
Fig. 3
Esters from the genus Celtis.
Fig. 3
Fig. 3
Esters from the genus Celtis.
Fig. 3
Fig. 3
Esters from the genus Celtis.
Fig. 4
Fig. 4
Flavonoids from the genus Celtis.
Fig. 4
Fig. 4
Flavonoids from the genus Celtis.
Fig. 4
Fig. 4
Flavonoids from the genus Celtis.
Fig. 5
Fig. 5
Organic acids from the genus Celtis.
Fig. 5
Fig. 5
Organic acids from the genus Celtis.
Fig. 5
Fig. 5
Organic acids from the genus Celtis.
Fig. 6
Fig. 6
Terpenoids from the genus Celtis.
Fig. 6
Fig. 6
Terpenoids from the genus Celtis.
Fig. 6
Fig. 6
Terpenoids from the genus Celtis.
Fig. 7
Fig. 7
Miscellaneous compounds from the genus Celtis.
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