Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 May 9;19(5):e0298774.
doi: 10.1371/journal.pone.0298774. eCollection 2024.

Systematic review and network meta-analysis on the efficacy and safety of parmacotherapy for hand osteoarthritis

Ruiqi Wu  1 , Qinglin Peng  1 , Weiwei Wang  1 , Jixian Zheng  2 , Yi Zhou  1 , Qipei Yang  1 , Xuan Zhang  1 , Hongyu Li  3 , Lin Meng  3
Affiliations
Meta-Analysis

Systematic review and network meta-analysis on the efficacy and safety of parmacotherapy for hand osteoarthritis

Ruiqi Wu et al. PLoS One. .

Abstract

Objective: Hand osteoarthritis poses a significant health challenge globally due to its increasing prevalence and the substantial burden on individuals and the society. In current clinical practice, treatment options for hand osteoarthritis encompass a range of approaches, including biological agents, antimetabolic drugs, neuromuscular blockers, anti-inflammatory drugs, hormone medications, pain relievers, new synergistic drugs, and other medications. Despite the diverse array of treatments, determining the optimal regimen remains elusive. This study seeks to conduct a network meta-analysis to assess the effectiveness and safety of various drug intervention measures in the treatment of hand osteoarthritis. The findings aim to provide evidence-based support for the clinical management of hand osteoarthritis.

Methods: We performed a comprehensive search across PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials was conducted until September 15th, 2022, to identify relevant randomized controlled trials. After meticulous screening and data extraction, the Cochrane Handbook's risk of bias assessment tool was applied to evaluate study quality. Data synthesis was carried out using Stata 15.1 software.

Results: 21 studies with data for 3965 patients were meta-analyzed, involving 20 distinct Western medicine agents. GCSB-5, a specific herbal complex that mainly regulate pain in hand osteoarthritis, showed the greatest reduction in pain [WMD = -13.00, 95% CI (-26.69, 0.69)]. CRx-102, s specific medication characterized by its significant effect for relieving joint stiffness symptoms, remarkably mitigated stiffness [WMD = -7.50, 95% CI (-8.90, -6.10)]. Chondroitin sulfate displayed the highest incidence of adverse events [RR = 0.26, 95% CI (0.06, 1.22)]. No substantial variation in functional index for hand osteoarthritis score improvement was identified between distinct agents and placebo.

Conclusions: In summary, GCSB-5 and CRx-102 exhibit efficacy in alleviating pain and stiffness in HOA, respectively. However, cautious interpretation of the results is advised. Tailored treatment decisions based on individual contexts are imperative.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The flow diagram of study selection.
Fig 2
Fig 2. Network diagram for pain.
Fig 3
Fig 3. Network diagram for stiffness.
Fig 4
Fig 4. Network diagram for FIHOA score.
Fig 5
Fig 5. Network diagram for adverse reaction rate.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Branco JC, Rodrigues AM, Gouveia N, Eusébio M, Ramiro S, Machado PM, et al.. Prevalence of rheumatic and musculoskeletal diseases and their impact on health-related quality of life, physical function and mental health in Portugal: results from EpiReumaPt- a national health survey. RMD open. 2016;2(1):e000166. doi: 10.1136/rmdopen-2015-000166 - DOI - PMC - PubMed
    1. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet (London, England). 2011;377(9783):2115–26. doi: 10.1016/S0140-6736(11)60243-2 - DOI - PubMed
    1. Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, et al.. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578–89. doi: 10.1016/j.joca.2019.06.011 - DOI - PubMed
    1. Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1145–53. doi: 10.1016/j.joca.2013.03.018 - DOI - PMC - PubMed
    1. Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, et al.. Osteoarthritis. Nature Reviews Disease Primers. 2016;2(1):16072. - PubMed

Publication types

Grants and funding

This study is supported and funded by the Project of Extension and Application of Appropriate Technology of Traditional Chinese Medicine in Guangxi Province (GZSY20-08, Grant Recipient: L. Meng), Guangxi Zhuang Autonomous Region Youth Qhuang Scholar Training Program (Guizhong Medical Science and Education [2022] No.13, Grant Recipient: L. Meng), Guangxi Natural Science Foundation Project (2021GXNSFAA196033, project leader: X. Zhang), and Guangxi TCM Appropriate Technology Development and Extension Project (GZSY21-78, funded by W.W. Wang). The The contributions of these authors are as follows, L. Meng: Funding acquisition, Supervision; X. Zhang: Supervision; W.W Wang: Formal analysis and investigation., We ensure that the funder of the Project of Extension and Application of Appropriate Technology of Traditional Chinese Medicine in Guangxi Province (GZSY20-08, Grant Recipient: L. Meng) and Guangxi Zhuang Autonomous Region Youth Qhuang Scholar Training Program (Guizhong Medical Science and Education [2022] No.13, Grant Recipient: L. Meng) has no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Xuan Zhang, the funder of Guangxi Natural Science Foundation Project (2021GXNSFAA196033) took charge of formal analysis, and Weiwei Wang, the funder of Guangxi TCM Appropriate Technology Development and Extension Project (GZSY21-78) took charge of data curation.