Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 15;8(6):bvae071.
doi: 10.1210/jendso/bvae071. eCollection 2024 Apr 6.

Concordance of Blood Glucose and CGM During a Pilot Trial of Automated Insulin Delivery in Type 1 Diabetes Pregnancies

Ravinder Jeet Kaur  1 , Carol J Levy  2 , Kristin Castorino  3 , Christina M Wood-Wentz  1 , Shafaq R Rizvi  1 , Basak Ozaslan  4 , Grenye O'Malley  2 , Mari Charisse Trinidad  1 , Camilla Levister  2 , Mei Mei Church  3 , Donna Desjardins  1 , Selassie Ogyaadu  2 , Corey Reid  1 , Kent R Bailey  1 , Francis J Doyle 3rd  4 , Jordan E Pinsker  3 , Eyal Dassau  3   4 , Yogish C Kudva  1
Affiliations

Concordance of Blood Glucose and CGM During a Pilot Trial of Automated Insulin Delivery in Type 1 Diabetes Pregnancies

Ravinder Jeet Kaur et al. J Endocr Soc. .

Abstract

Background: Customized and standard automated insulin delivery (AID) systems for use in pregnancies of women with preexisting type 1 diabetes (T1D) are being developed and tested to achieve pregnancy appropriate continuous glucose monitoring (CGM) targets. Guidance on the use of CGM for treatment decisions during pregnancy in the United States is limited.

Methods: Ten pregnant women with preexisting T1D participated in a trial evaluating at-home use of a pregnancy-specific AID system. Seven-point self-monitoring of blood glucose (SMBG) was compared to the closest sensor glucose (Dexcom G6 CGM) value biweekly to assess safety and reliability based on the 20%/20 mg/dL criteria.

Results: All participants completed the study with 7 participants satisfying the safety and reliability criteria with a mean absolute relative difference of 10.3%. Three participants did not fulfill the criteria, mainly because the frequency of SMBG did not meet the requirements.

Conclusion: Dexcom G6 CGM is safe and accurate in the real-world setting for use in pregnant women with preexisting T1D with reduced SMBG testing as part of a pregnancy-specific AID system.

Keywords: automated insulin delivery; continuous glucose monitoring; outpatient; pregnancy; self-monitoring blood glucose; type 1 diabetes.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Holmes VA, Young IS, Patterson CC, et al. . Optimal glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes in the diabetes and pre-eclampsia intervention trial. Diabetes Care 2011;34(8):1683‐1688. - PMC - PubMed
    1. Maresh MJ, Holmes VA, Patterson CC, et al. . Glycemic targets in the second and third trimester of pregnancy for women with type 1 diabetes. Diabetes Care 2015;38(1):34‐42. - PubMed
    1. Cohen O, Keidar N, Simchen M, Weisz B, Dolitsky M, Sivan E. Macrosomia in well controlled CSII treated type I diabetic pregnancy. Gynecol Endocrinol 2008;24(11):611‐613. - PubMed
    1. Ekbom P, Damm P, Feldt-Rasmussen B, Feldt-Rasmussen U, Jensen DM, Mathiesen ER. Elevated third-trimester haemoglobin A 1c predicts preterm delivery in type 1 diabetes. J Diabetes Complications 2008;22(5):297‐302. - PubMed
    1. Persson M, Norman M, Hanson U. Obstetric and perinatal outcomes in type 1 diabetic pregnancies: a large, population-based study. Diabetes Care 2009;32(11):2005‐2009. - PMC - PubMed

LinkOut - more resources